Literature DB >> 18083561

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Zhijian Zhao1, Scott E Wolkenberg, Philip E J Sanderson, Meiqing Lu, Vandna Munshi, Gregory Moyer, Meizhen Feng, Anthony V Carella, Linda T Ecto, Lori J Gabryelski, Ming-Tain Lai, Sridar G Prasad, Youwei Yan, Georgia B McGaughey, Michael D Miller, Craig W Lindsley, George D Hartman, Joseph P Vacca, Theresa M Williams.   

Abstract

This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.

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Year:  2007        PMID： 18083561     DOI： 10.1016/j.bmcl.2007.11.085

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.

Authors:  Hua-Poo Su; Youwei Yan; G Sridhar Prasad; Robert F Smith; Christopher L Daniels; Pravien D Abeywickrema; John C Reid; H Marie Loughran; Maria Kornienko; Sujata Sharma; Jay A Grobler; Bei Xu; Vinod Sardana; Timothy J Allison; Peter D Williams; Paul L Darke; Daria J Hazuda; Sanjeev Munshi
Journal:  J Virol       Date:  2010-05-19       Impact factor: 5.103

2.  Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.

Authors:  Mohammad Hassam; Adriaan E Basson; Dennis C Liotta; Lynn Morris; Willem A L van Otterlo; Stephen C Pelly
Journal:  ACS Med Chem Lett       Date:  2012-05-02       Impact factor: 4.345

3.  Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

Authors:  Dongwei Kang; Xiao Ding; Gaochan Wu; Zhipeng Huo; Zhongxia Zhou; Tong Zhao; Da Feng; Zhao Wang; Ye Tian; Dirk Daelemans; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Xinyong Liu
Journal:  ACS Med Chem Lett       Date:  2017-10-19       Impact factor: 4.345

4.  Dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade.

Authors:  Mindaugas Šiaučiulis; Selma Sapmaz; Alexander P Pulis; David J Procter
Journal:  Chem Sci       Date:  2017-11-17       Impact factor: 9.825

Review 5.  A review on recent developments of indole-containing antiviral agents.

Authors:  Ming-Zhi Zhang; Qiong Chen; Guang-Fu Yang
Journal:  Eur J Med Chem       Date:  2014-10-23       Impact factor: 6.514

6.  Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies.

Authors:  Assem Barakat; Ahmed Mostafa; M Ali; Abdullah Mohammed Al-Majid; Luis R Domingo; Omnia Kutkat; Yassmin Moatasim; Komal Zia; Zaheer Ul-Haq; Yaseen A M M Elshaier
Journal:  Int J Mol Sci       Date:  2022-10-06       Impact factor: 6.208

7.  Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization.

Authors:  Piyush Kumar Agarwal; Meena Devi Dathi; Mohammad Saifuddin; Bijoy Kundu
Journal:  Beilstein J Org Chem       Date:  2012-11-08       Impact factor: 2.883

8.  Synthesis and biological evaluation of new nanosized aromatic polyamides containing amido- and sulfonamidopyrimidines pendant structures.

Authors:  Hammed H A M Hassan; Elsayed M E Mansour; Asmaa M S Abou Zeid; Ehab R El-Helow; Amel F Elhusseiny; Raafat Soliman
Journal:  Chem Cent J       Date:  2015-08-19       Impact factor: 4.215

9.  Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase.

Authors:  Akiyoshi Nakamura; Noriko Tamura; Yoshiaki Yasutake
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-10-23       Impact factor: 1.056

Review 10.  Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors.

Authors:  Valeria Famiglini; Romano Silvestri
Journal:  Antivir Chem Chemother       Date:  2018 Jan-Dec
  10 in total

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