| Literature DB >> 18078453 |
M C Picinato1, A E Hirata, J Cipolla-Neto, R Curi, C R O Carvalho, G F Anhê, A R Carpinelli.
Abstract
Melatonin diminishes insulin release through the activation of MT1 receptors and a reduction in cAMP production in isolated pancreatic islets of neonate and adult rats and in INS-1 cells (an insulin-secreting cell line). The pancreas of pinealectomized rats exhibits degenerative pathological changes with low islet density, indicating that melatonin plays a role to ensure the functioning of pancreatic beta cells. By using immunoprecipitation and immunoblotting analysis we demonstrated, in isolated rat pancreatic islets, that melatonin induces insulin growth factor receptor (IGF-R) and insulin receptor (IR) tyrosine phosphorylation and mediates the activities of the PI3K/AKT and MEK/ERKs pathways, which are involved in cell survival and growth, respectively. Thus, the effects of melatonin on pancreatic islets do not involve a reduction in cAMP levels only. This indoleamine may regulate growth and differentiation of pancreatic islets by activating IGF-I and insulin receptor signaling pathways.Entities:
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Year: 2008 PMID： 18078453 DOI： 10.1111/j.1600-079X.2007.00493.x
Source DB: PubMed Journal: J Pineal Res ISSN： 0742-3098 Impact factor: 13.007