Literature DB >> 18078333

Highly effective DNA photocleavage by novel "rigid" Ru(bpy)(3)-4-nitro- and -4-amino-1,8-naphthalimide conjugates.

Gary J Ryan1, Susan Quinn, Thorfinnur Gunnlaugsson.   

Abstract

The synthesis of the two novel 1,8-naphthalimideruthenium conjugates Ru-Nap-NO(2) and Ru-Nap-NH(2) and their photophysical evaluation upon interaction with DNA is reported. Significant changes were seen in both the absorption and emission spectra upon interaction of both conjugates with DNA, from which large binding constants were determined. Moreover, highly efficient DNA cleavage was observed upon irradiation for 5 min, during which supercoiled DNA was converted to nicked and linear DNA by Ru-Nap-NH(2).

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Year:  2007        PMID： 18078333     DOI： 10.1021/ic700967y

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  6 in total

1.  Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy.

Authors:  James P Hall; Fergus E Poynton; Páraic M Keane; Sarah P Gurung; John A Brazier; David J Cardin; Graeme Winter; Thorfinnur Gunnlaugsson; Igor V Sazanovich; Michael Towrie; Christine J Cardin; John M Kelly; Susan J Quinn
Journal:  Nat Chem       Date:  2015-10-19       Impact factor: 24.427

2.  Biophysical insights into the interaction of two enantiomers of Ru(II) complex [Ru(bpy)2(7-CH3-dppz)]2+ with the RNA poly(U-A⁎U) triplex.

Authors:  Zhan Dong; Xiaohua Liu; Lifeng Tan
Journal:  J Biol Inorg Chem       Date:  2020-10-11       Impact factor: 3.358

3.  Synthesis, Spectral Properties and DFT Calculations of new Ruthenium (II) Polypyridyl Complexes; DNA Binding Affinity and in Vitro Cytotoxicity Activity.

Authors:  Rajender Reddy Mallepally; Nagamani Chintakuntla; Venkat Reddy Putta; Nagasuryaprasad K; Ravi Kumar Vuradi; Madhuri P; Satyanarayana Singh S; Ramesh Kumar Chitumalla; Joonkyung Jang; Nagababu Penumaka; Satyanarayana Sirasani
Journal:  J Fluoresc       Date:  2017-04-22       Impact factor: 2.217

4.  Photochemically active DNA-intercalating ruthenium and related complexes - insights by combining crystallography and transient spectroscopy.

Authors:  Christine J Cardin; John M Kelly; Susan J Quinn
Journal:  Chem Sci       Date:  2017-04-12       Impact factor: 9.825

5.  Hook, Line, and Sinker! Spectroscopic Studies of Bi-Modular Mono- and Bis-1,8-naphthalimide-Ru(bpy)3-conjugates as DNA "Light Switches".

Authors:  Gary J Ryan; Thorfinnur Gunnlaugsson; Susan J Quinn
Journal:  Inorg Chem       Date:  2022-07-25       Impact factor: 5.436

6.  DNA-Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light.

Authors:  Huayun Shi; Jana Kasparkova; Clément Soulié; Guy J Clarkson; Cinzia Imberti; Olga Novakova; Martin J Paterson; Viktor Brabec; Peter J Sadler
Journal:  Chemistry       Date:  2021-05-27       Impact factor: 5.020
  6 in total

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