Literature DB >> 18070975

Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?

Stéphanie Matrat1, Emmanuelle Cambau, Vincent Jarlier, Alexandra Aubry.   

Abstract

Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.

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Year:  2007        PMID： 18070975      PMCID： PMC2224767          DOI： 10.1128/AAC.01095-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Review 2.  Recent advances in the chemotherapy of leprosy.

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Journal:  Lepr Rev       Date:  1990-12       Impact factor: 0.537

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Authors:  S R Pattyn
Journal:  Int J Lepr Other Mycobact Dis       Date:  1991-12

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Authors:  B Ji; J Grosset
Journal:  Lepr Rev       Date:  2000-12       Impact factor: 0.537

5.  Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones.

Authors:  Stéphanie Matrat; Stéphanie Petrella; Emmanuelle Cambau; Wladimir Sougakoff; Vincent Jarlier; Alexandra Aubry
Journal:  Antimicrob Agents Chemother       Date:  2007-02-26       Impact factor: 5.191

6.  Multidrug resistant Mycobacterium leprae from patients with leprosy.

Authors:  S Maeda; M Matsuoka; N Nakata; M Kai; Y Maeda; K Hashimoto; H Kimura; K Kobayashi; Y Kashiwabara
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

7.  Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCR.

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Review 8.  Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection.

Authors:  Joaquim Ruiz
Journal:  J Antimicrob Chemother       Date:  2003-04-14       Impact factor: 5.790

Review 9.  Advances in the diagnosis and treatment of leprosy.

Authors:  Vishwa M Katoch
Journal:  Expert Rev Mol Med       Date:  2002-07-22       Impact factor: 5.600

10.  Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.

Authors:  Alexandra Aubry; Xiao-Su Pan; L Mark Fisher; Vincent Jarlier; Emmanuelle Cambau
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191
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  6 in total

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Authors:  Emmanuelle Cambau; Aurélie Chauffour-Nevejans; Liana Tejmar-Kolar; Masanori Matsuoka; Vincent Jarlier
Journal:  PLoS Negl Trop Dis       Date:  2012-07-31

4.  Impact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistance.

Authors:  Kazumasa Yokoyama; Hyun Kim; Tetsu Mukai; Masanori Matsuoka; Chie Nakajima; Yasuhiko Suzuki
Journal:  PLoS Negl Trop Dis       Date:  2012-10-11

5.  Resistance of M. leprae to quinolones: a question of relativity?

Authors:  Nicolas Veziris; Aurélie Chauffour; Sylvie Escolano; Sarah Henquet; Masanori Matsuoka; Vincent Jarlier; Alexandra Aubry
Journal:  PLoS Negl Trop Dis       Date:  2013-11-14

6.  DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae.

Authors:  Tomoyuki Yamaguchi; Kazumasa Yokoyama; Chie Nakajima; Yasuhiko Suzuki
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  6 in total

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