Literature DB >> 18070965

Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.

Fiona L Henriquez1, Paul R Ingram, Stephen P Muench, David W Rice, Craig W Roberts.   

Abstract

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

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Year:  2007        PMID： 18070965      PMCID： PMC2258519          DOI： 10.1128/AAC.00355-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

Review 1.  Tubulin as an antiprotozoal drug target.

Authors:  Karl A Werbovetz
Journal:  Mini Rev Med Chem       Date:  2002-12       Impact factor: 3.862

Review 2.  The biochemistry of compounds with anti-microtubule activity in plant cells.

Authors:  L C Morejohn; D E Fosket
Journal:  Pharmacol Ther       Date:  1991       Impact factor: 12.310

3.  Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in beta-tubulin isotype 1.

Authors:  M S Kwa; J G Veenstra; M H Roos
Journal:  Mol Biochem Parasitol       Date:  1994-02       Impact factor: 1.759

4.  Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum.

Authors:  Louisa M MacDonald; Anthony Armson; Andrew R C Thompson; James A Reynoldson
Journal:  Mol Biochem Parasitol       Date:  2004-11       Impact factor: 1.759

5.  Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba.

Authors:  James McBride; Paul R Ingram; Fiona L Henriquez; Craig W Roberts
Journal:  J Clin Microbiol       Date:  2005-02       Impact factor: 5.948

6.  Rapid and Reversible High-Affinity Binding of the Dinitroaniline Herbicide Oryzalin to Tubulin from Zea mays L.

Authors:  J. D. Hugdahl; L. C. Morejohn
Journal:  Plant Physiol       Date:  1993-07       Impact factor: 8.340

7.  Sequence divergence of Entamoeba histolytica tubulin is responsible for its altered tertiary structure.

Authors:  Debjani Roy; Anuradha Lohia
Journal:  Biochem Biophys Res Commun       Date:  2004-07-02       Impact factor: 3.575

8.  Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence.

Authors:  S K Katiyar; V R Gordon; G L McLaughlin; T D Edlind
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

9.  Dinitroanilines bind alpha-tubulin to disrupt microtubules.

Authors:  Naomi S Morrissette; Arpita Mitra; David Sept; L David Sibley
Journal:  Mol Biol Cell       Date:  2004-01-23       Impact factor: 4.138

10.  Clinical pharmacokinetics of albendazole in patients with brain cysticercosis.

Authors:  H Jung; M Hurtado; M Sanchez; M T Medina; J Sotelo
Journal:  J Clin Pharmacol       Date:  1992-01       Impact factor: 3.126
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  8 in total

1.  Liver fluke β-tubulin isotype 2 binds albendazole and is thus a probable target of this drug.

Authors:  Emma Chambers; Louise A Ryan; Elizabeth M Hoey; Alan Trudgett; Neil V McFerran; Ian Fairweather; David J Timson
Journal:  Parasitol Res       Date:  2010-07-31       Impact factor: 2.289

2.  Cytotoxic activity and degradation patterns of structural proteins by corneal isolates of Acanthamoeba spp.

Authors:  Viviane Peracini Sant'ana; Linda Christian Carrijo-Carvalho; Annette Silva Foronda; Ana Marisa Chudzinski-Tavassi; Denise de Freitas; Fábio Ramos Souza de Carvalho
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2014-08-27       Impact factor: 3.117

3.  In vitro evaluation of antimicrobial agents on Acanthamoeba sp. and evidence of a natural resilience to amphotericin B.

Authors:  Alexandre Taravaud; Philippe M Loiseau; Sébastien Pomel
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2017-09-08       Impact factor: 4.077

4.  Kinetics of Mimivirus Infection Stages Quantified Using Image Flow Cytometry.

Authors:  Liran Ben Yaakov; Yael Mutsafi; Ziv Porat; Tali Dadosh; Abraham Minsky
Journal:  Cytometry A       Date:  2019-04-24       Impact factor: 4.355

5.  Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking.

Authors:  Samia A Elseginy; A Sofia F Oliveira; Deborah K Shoemark; Richard B Sessions
Journal:  RSC Med Chem       Date:  2022-05-18

6.  Homology Modeling, Molecular Docking, Molecular Dynamic Simulation, and Drug-Likeness of the Modified Alpha-Mangostin against the β-Tubulin Protein of Acanthamoeba Keratitis.

Authors:  Tassanee Ongtanasup; Anisha Mazumder; Anupma Dwivedi; Komgrit Eawsakul
Journal:  Molecules       Date:  2022-09-26       Impact factor: 4.927

7.  Comparison of Epothilone and Taxol Binding in Yeast Tubulin using Molecular Modeling.

Authors:  Vajihe Akbari; Sharareh Moghim; Mohammad Reza Mofid
Journal:  Avicenna J Med Biotechnol       Date:  2011-10

8.  Comparative analyses of the β-tubulin gene and molecular modeling reveal molecular insight into the colchicine resistance in kinetoplastids organisms.

Authors:  Luis Luis; María Luisa Serrano; Mariana Hidalgo; Alexis Mendoza-León
Journal:  Biomed Res Int       Date:  2013-09-08       Impact factor: 3.411
  8 in total

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