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Literature DB >> 12370037

Tubulin as an antiprotozoal drug target.

Abstract

Since tubulin is a known anticancer and anthelmintic drug target, the investigation of protozoal tubulin could lead to the development of new antiparasitic drugs. This review outlines the current state of knowledge concerning drug-mammalian tubulin interactions, the effects of antimicrotubule agents on parasites and parasite tubulin, and our current hypotheses regarding the development of selective ligands for protozoal tubulin as antiparasitic drug candidates.

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Year: 2002 PMID： 12370037 DOI： 10.2174/1389557023405648

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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Cited

16 in total

1. Cell structure and cytokinesis alterations in multidrug-resistant Leishmania (Leishmania) amazonensis.

Authors: V M Borges; U G Lopes; W De Souza; M A Vannier-Santos
Journal: Parasitol Res Date: 2004-12-10 Impact factor: 2.289

2. α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance.

Authors: Sally Lyons-Abbott; Dan L Sackett; Dorota Wloga; Jacek Gaertig; Rachel E Morgan; Karl A Werbovetz; Naomi S Morrissette
Journal: Eukaryot Cell Date: 2010-09-24

3. Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.

Authors: Fiona L Henriquez; Paul R Ingram; Stephen P Muench; David W Rice; Craig W Roberts
Journal: Antimicrob Agents Chemother Date: 2007-12-10 Impact factor: 5.191

4. Synthesis and biological evaluation of selective tubulin inhibitors as anti-trypanosomal agents.

Authors: Viharika Bobba; Vishal Nanavaty; Nethrie D Idippily; Anran Zhao; Bibo Li; Bin Su
Journal: Bioorg Med Chem Date: 2017-04-08 Impact factor: 3.641

5. An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization.

Authors: Imran Ullah; Suraksha Gahalawat; Laela M Booshehri; Hanspeter Niederstrasser; Shreoshi Majumdar; Christopher Leija; James M Bradford; Bin Hu; Joseph M Ready; Dawn M Wetzel
Journal: ACS Infect Dis Date: 2020-07-20 Impact factor: 5.084

Tubulin as an antiprotozoal drug target.

1. Cell structure and cytokinesis alterations in multidrug-resistant Leishmania (Leishmania) amazonensis.

2. α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance.

3. Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.

4. Synthesis and biological evaluation of selective tubulin inhibitors as anti-trypanosomal agents.

5. An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization.

6. Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.

7. Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine.

8. Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents.

9. Evaluation of the growth-inhibitory effect of trifluralin analogues on in vitro cultured Babesia bovis parasites.

10. Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.