Huibin Qi1, Jiande D Z Chen. 1. University of Texas Medical Branch, Division of Gastroenterology, Route 0632, Room 221 Microbiology Bldg., 1108 The Strand, Galveston, TX 77555-0632, USA.
Abstract
BACKGROUND: Intestinal electrical stimulation (IES) with long pulses has been reported to inhibit motility as well as accelerate transit of continuous infusion. However, it is unknown whether there is a correlation between the IES-induced alterations in motility and transit and whether there is a difference in transit during IES between continuous infusion and bolus infusion. METHODS: The study was performed in 2 postprandial sessions (control and stimulation) in dogs with 2 pairs of serosal electrodes and 2 intestinal cannulas. Intestinal motility and transit with and without IES were measured by manometry and phenol red, respectively. RESULTS: IES significantly decreased intestinal motility and increased transit time. There was a significant correlation between motility index and transit during IES. CONCLUSIONS: IES inhibits both intestinal bolus motility and transit. There is correlation between motility and transit during IES.
BACKGROUND: Intestinal electrical stimulation (IES) with long pulses has been reported to inhibit motility as well as accelerate transit of continuous infusion. However, it is unknown whether there is a correlation between the IES-induced alterations in motility and transit and whether there is a difference in transit during IES between continuous infusion and bolus infusion. METHODS: The study was performed in 2 postprandial sessions (control and stimulation) in dogs with 2 pairs of serosal electrodes and 2 intestinal cannulas. Intestinal motility and transit with and without IES were measured by manometry and phenol red, respectively. RESULTS:IES significantly decreased intestinal motility and increased transit time. There was a significant correlation between motility index and transit during IES. CONCLUSIONS:IES inhibits both intestinal bolus motility and transit. There is correlation between motility and transit during IES.