Jun Song1, Jieyun Yin2, Jiande Chen3. 1. Division of Gastroenterology, University of Texas Medical Branch Galveston, Texas ; Department of Gastroenterology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China. 2. Division of Gastroenterology, University of Texas Medical Branch Galveston, Texas. 3. Division of Gastroenterology, University of Texas Medical Branch Galveston, Texas ; Ningbo Pace Translational Medical Research Center Beilun, Ningbo, China.
Abstract
AIM: This study was designed to compare the effects and mechanisms of transcutaneous electroacupuncture (TEA) on rectal distention (RD)-induced intestinal dysmotility with EA. METHODS: six female dogs chronically implanted with a duodenal fistula, a proximal colon fistula and intestinal serosal electrodes were studied. EA and TEA were performed via needles and cutaneous electrodes placed at bilateral ST-36 (Zusanli) acupoints respectively; their effects on postprandial intestinal dysmotility (slow waves, contractions and transit) induced by RD, and autonomic functions were compared. RESULTS: RD at a volume of 140 ml suppressed intestinal contractions; the motility index was reduced with RD (P = 0.001). Both EA and TEA ameliorated the suppressed contractions (P = 0.003 and 0.001) and their effects were comparable. RD reduced the percentage of normal intestinal slow waves (P = 0.002) that was increased with both EA and TEA (P = 0.005 and 0.035). No significant difference was noted between EA and TEA. EA and TEA reduced small bowel transit time (P = 0.001 and 0.007); these prokinetic effects were blocked by atropine. Both EA and TEA increased vagal activity assessed by the spectral analysis of heart rate variability (both P = 0.03). CONCLUSION: RD inhibits postprandial intestinal motility. Both EA and TEA at ST-36 are able to improve the RD-induced impairment in intestinal contractions, transit and slow waves mediated via the vagal mechanism. Needleless TEA is as effective as EA in ameliorating the intestinal hypomotility.
AIM: This study was designed to compare the effects and mechanisms of transcutaneous electroacupuncture (TEA) on rectal distention (RD)-induced intestinal dysmotility with EA. METHODS: six female dogs chronically implanted with a duodenal fistula, a proximal colon fistula and intestinal serosal electrodes were studied. EA and TEA were performed via needles and cutaneous electrodes placed at bilateral ST-36 (Zusanli) acupoints respectively; their effects on postprandial intestinal dysmotility (slow waves, contractions and transit) induced by RD, and autonomic functions were compared. RESULTS: RD at a volume of 140 ml suppressed intestinal contractions; the motility index was reduced with RD (P = 0.001). Both EA and TEA ameliorated the suppressed contractions (P = 0.003 and 0.001) and their effects were comparable. RD reduced the percentage of normal intestinal slow waves (P = 0.002) that was increased with both EA and TEA (P = 0.005 and 0.035). No significant difference was noted between EA and TEA. EA and TEA reduced small bowel transit time (P = 0.001 and 0.007); these prokinetic effects were blocked by atropine. Both EA and TEA increased vagal activity assessed by the spectral analysis of heart rate variability (both P = 0.03). CONCLUSION: RD inhibits postprandial intestinal motility. Both EA and TEA at ST-36 are able to improve the RD-induced impairment in intestinal contractions, transit and slow waves mediated via the vagal mechanism. Needleless TEA is as effective as EA in ameliorating the intestinal hypomotility.
Authors: Vladimir P Zagorodnyuk; Melinda Kyloh; Sarah Nicholas; Heshan Peiris; Simon J Brookes; Bao Nan Chen; Nick J Spencer Journal: J Physiol Date: 2011-02-14 Impact factor: 5.182
Authors: Tatiana E Salazar; Matthew R Richardson; Eleni Beli; Matthew S Ripsch; John George; Youngsook Kim; Yaqian Duan; Leni Moldovan; Yuanqing Yan; Ashay Bhatwadekar; Vaishnavi Jadhav; Jared A Smith; Susan McGorray; Alicia L Bertone; Dmitri O Traktuev; Keith L March; Luis M Colon-Perez; Keith G Avin; Emily Sims; Julie A Mund; Jamie Case; Xiaolin Deng; Min Su Kim; Bruce McDavitt; Michael E Boulton; Jeffrey Thinschmidt; Sergio Li Calzi; Stephanie D Fitz; Robyn K Fuchs; Stuart J Warden; Todd McKinley; Anantha Shekhar; Marcelo Febo; Phillip L Johnson; Lung-Ji Chang; Zhanguo Gao; Mikhail G Kolonin; Song Lai; Jingfeng Ma; Xinzhong Dong; Fletcher A White; Huisheng Xie; Mervin C Yoder; Maria B Grant Journal: Stem Cells Date: 2017-05 Impact factor: 6.277