| Literature DB >> 18064641 |
Ronald D Barr1, Alessandra Sala.
Abstract
Osteonecrosis is recognized increasingly as a complication of the treatment of cancer in young people, especially those with acute lymphoblastic leukemia and non-Hodgkin lymphoma, reflecting a probable pathogenetic role of steroid therapy. Children >/=10 years of age and Whites are at particular risk, and genetic predispositions have been identified. The disorder affects weight-bearing joints predominantly. It is commonly bilateral and multi-articular. Treatment options include both surgical and non-surgical interventions. (c) 2007 Wiley-Liss, Inc.Entities:
Mesh:
Year: 2008 PMID: 18064641 DOI: 10.1002/pbc.21405
Source DB: PubMed Journal: Pediatr Blood Cancer ISSN: 1545-5009 Impact factor: 3.167