D Ippolito1,2, A Masetto3,4, C Talei Franzesi3,4, P A Bonaffini3,4, A Sala3,5, A Biondi3,5, S Sironi3,4. 1. School of Medicine, University of Milano-Bicocca Milan, Via Pergolesi 33, 20900, Monza (MB), Italy. davide.atena@tiscalinet.it. 2. Department of Diagnostic Radiology, H. San Gerardo, Via Pergolesi 33, 20900, Monza (MB), Italy. davide.atena@tiscalinet.it. 3. School of Medicine, University of Milano-Bicocca Milan, Via Pergolesi 33, 20900, Monza (MB), Italy. 4. Department of Diagnostic Radiology, H. San Gerardo, Via Pergolesi 33, 20900, Monza (MB), Italy. 5. Department of Paediatric Haematology, H S. Gerardo, Via Pergolesi 33, 20900, Monza (MB), Italy.
Abstract
PURPOSE: To assess the diagnostic value of MRI examination in detecting and monitoring osteonecrotic lesions (ON) in childhood acute lymphoblastic leukaemia (ALL) after chemotherapy (CHT) and/or bone marrow transplantation (BMT). METHODS AND MATERIALS: Seventy-three patients (37 males, mean age 12.4 years old) with ALL after treatment underwent a lower-limb MR examination between November 2006 and March 2012. In 47 there was clinical suspicion of ON, 26 were asymptomatic. Studies were performed with a 1 T and a 1.5 T scanner, acquiring short tau inversion recovery (STIR) and T1-weighted sequences in coronal plane from the hips to the ankles. The average acquisition time was 18 min. Considering baseline and follow-up examinations, the overall number of MRI studies was 195. RESULTS: Fifty-four of 73 patients showed ON at MRI study, with an overall number of 323 ON (89 involving articular surface, 24 with joint deformity, JD). Twenty-five of 47 symptomatic patients showed subchondral ON lesions, 11 developed JD. Three of 26 asymptomatic patients showed subchondral bone ON at baseline examination but no JD at follow-up. Twenty-two of 28 BMT, 32/45 CHT patients developed ON. CONCLUSION: Our MRI protocol proved to be feasible in evaluating ON in paediatric patients. Studies should be addressed only to symptomatic patients.
PURPOSE: To assess the diagnostic value of MRI examination in detecting and monitoring osteonecrotic lesions (ON) in childhood acute lymphoblastic leukaemia (ALL) after chemotherapy (CHT) and/or bone marrow transplantation (BMT). METHODS AND MATERIALS: Seventy-three patients (37 males, mean age 12.4 years old) with ALL after treatment underwent a lower-limb MR examination between November 2006 and March 2012. In 47 there was clinical suspicion of ON, 26 were asymptomatic. Studies were performed with a 1 T and a 1.5 T scanner, acquiring short tau inversion recovery (STIR) and T1-weighted sequences in coronal plane from the hips to the ankles. The average acquisition time was 18 min. Considering baseline and follow-up examinations, the overall number of MRI studies was 195. RESULTS: Fifty-four of 73 patients showed ON at MRI study, with an overall number of 323 ON (89 involving articular surface, 24 with joint deformity, JD). Twenty-five of 47 symptomatic patients showed subchondral ON lesions, 11 developed JD. Three of 26 asymptomatic patients showed subchondral bone ON at baseline examination but no JD at follow-up. Twenty-two of 28 BMT, 32/45 CHT patients developed ON. CONCLUSION: Our MRI protocol proved to be feasible in evaluating ON in paediatric patients. Studies should be addressed only to symptomatic patients.
Authors: J D Rizzo; J R Wingard; A Tichelli; S J Lee; M T Van Lint; L J Burns; S M Davies; J L M Ferrara; G Socié Journal: Bone Marrow Transplant Date: 2006-02 Impact factor: 5.483
Authors: Jitesh D Kawedia; Sue C Kaste; Deqing Pei; John C Panetta; Xiangjun Cai; Cheng Cheng; Geoffrey Neale; Scott C Howard; William E Evans; Ching-Hon Pui; Mary V Relling Journal: Blood Date: 2010-12-10 Impact factor: 22.113
Authors: S Sharma; S Yang; R Rochester; L Britton; W H Leung; J Yang; M D Neel; K K Ness; S C Kaste Journal: Bone Marrow Transplant Date: 2010-09-06 Impact factor: 5.483