| Literature DB >> 18063445 |
Laurent Mascarell1, Laurence Van Overtvelt, Vincent Lombardi, Alain Razafindratsita, Hélène Moussu, Stéphane Horiot, Henri Chabre, David Limal, Stéphane Moutel, Jacques Bauer, Carlo Chiavaroli, Philippe Moingeon.
Abstract
In this study, we tested two triacylated pseudo-dipeptidic molecules, OM-197-MP-AC and OM-294-BA-MP as candidate adjuvants for allergy vaccines. Both molecules induce human dendritic cell (h-DC) maturation and polarize naïve T cells toward the Th1 type with IFNgamma production. Only OM-294-BA-MP induces IL10 gene expression both in monocyte-derived DCs and CD4+ naïve T cells. Sublingual administration of OM-294-BA-MP plus the antigen enhances tolerance induction in BALB/c mice with established asthma to ovalbumin with an impact on both airways hyperresponsiveness and lung inflammation. Given its Th1/Treg polarizing properties, OM-294-BA-MP is a valid candidate for sublingual allergy vaccines.Entities:
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Year: 2007 PMID： 18063445 DOI： 10.1016/j.vaccine.2007.10.050
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641