Literature DB >> 18848884

Towards a cure for food allergy.

Justin M Skripak1, Hugh A Sampson.   

Abstract

Over the past two decades, food allergies have become both more prevalent and long lasting. This burgeoning problem has not been met with any therapeutic options to date, and patients must attempt to avoid known allergenic foods and treat any allergic reactions with 'as-needed' medications. There are a number of promising emerging therapeutic modalities for food allergy, including allergen-specific and allergen non-specific immunotherapeutic approaches. Although the allergen-specific approaches have some distinct differences, they all attempt to induce tolerance by exposing the patient to an allergen via the mucosal route (oral tolerance induction). Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication).

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Year:  2008        PMID: 18848884      PMCID: PMC2605785          DOI: 10.1016/j.coi.2008.09.002

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN: 0952-7915            Impact factor:   7.486


  50 in total

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6.  Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy.

Authors:  L Vila; K Beyer; K M Järvinen; P Chatchatee; L Bardina; H A Sampson
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7.  Paediatric anaphylaxis: a 5 year retrospective review.

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8.  Induction of tolerance after establishment of peanut allergy by the food allergy herbal formula-2 is associated with up-regulation of interferon-gamma.

Authors:  C Qu; K Srivastava; J Ko; T F Zhang; H A Sampson; X-M Li
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9.  Improvement of sublingual immunotherapy efficacy with a mucoadhesive allergen formulation.

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