| Literature DB >> 18063227 |
Liliana M Finkielsztein1, Eliana F Castro, Lucas E Fabián, Graciela Y Moltrasio, Rodolfo H Campos, Lucía V Cavallaro, Albertina G Moglioni.
Abstract
Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI=80.29) than that of ribavirin (SI=11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus.Entities:
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Year: 2007 PMID： 18063227 DOI： 10.1016/j.ejmech.2007.10.023
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514