OBJECTIVE: The purpose of this study was to examine whether maternal corticosteroid use during pregnancy is associated with delivering an infant with an orofacial cleft. STUDY DESIGN: This study included data on deliveries from the National Birth Defects Prevention Study, which is a population-based case-control study. Exposures were assessed by telephone interviews for mothers of 1141 cases with cleft lip +/- cleft palate (CLP), 628 with cleft palate (CP), and 4143 controls. RESULTS: Mothers of 33 infants with CLP (2.9%), mothers of 6 infants with CP (1.0%), and 72 control subjects (1.7%) reported corticosteroid use from 4 weeks before through 12 weeks after conception. The crude odds ratio for "any" vs "no" use was 1.7 (95% CI, 1.1-2.6) for CLP and 0.5 (0.2-1.3) for CP. When analyzed by route of administration and medication components, odds ratios for CLP tended to be elevated, and odds ratios for CP tended to be close to 1. CONCLUSION: Our results suggest a moderately increased risk of CLP among women who use corticosteroids during early pregnancy.
OBJECTIVE: The purpose of this study was to examine whether maternal corticosteroid use during pregnancy is associated with delivering an infant with an orofacial cleft. STUDY DESIGN: This study included data on deliveries from the National Birth Defects Prevention Study, which is a population-based case-control study. Exposures were assessed by telephone interviews for mothers of 1141 cases with cleft lip +/- cleft palate (CLP), 628 with cleft palate (CP), and 4143 controls. RESULTS: Mothers of 33 infants with CLP (2.9%), mothers of 6 infants with CP (1.0%), and 72 control subjects (1.7%) reported corticosteroid use from 4 weeks before through 12 weeks after conception. The crude odds ratio for "any" vs "no" use was 1.7 (95% CI, 1.1-2.6) for CLP and 0.5 (0.2-1.3) for CP. When analyzed by route of administration and medication components, odds ratios for CLP tended to be elevated, and odds ratios for CP tended to be close to 1. CONCLUSION: Our results suggest a moderately increased risk of CLP among women who use corticosteroids during early pregnancy.
Authors: M Shane Hutson; Maxwell C K Leung; Nancy C Baker; Richard M Spencer; Thomas B Knudsen Journal: Chem Res Toxicol Date: 2017-01-20 Impact factor: 3.739
Authors: Hildur Skuladottir; Allen Wilcox; Robert McConnaughey; Hallvard Vindenes; Rolv T Lie Journal: Ann Epidemiol Date: 2014-07-08 Impact factor: 3.797
Authors: Vijaya Kancherla; Paul A Romitti; Lixian Sun; John C Carey; Trudy L Burns; Anna Maria Siega-Riz; Charlotte M Druschel; Angela E Lin; Richard S Olney Journal: Eur J Med Genet Date: 2014-02-24 Impact factor: 2.708