| Literature DB >> 18060855 |
Kayo Kuroyanagi1, Min-Sook Kang, Tsuyoshi Goto, Shizuka Hirai, Kana Ohyama, Tatsuya Kusudo, Rina Yu, Masamichi Yano, Takao Sasaki, Nobuyuki Takahashi, Teruo Kawada.
Abstract
Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-alpha and PPARgamma. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARgamma antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARgamma activations. The results indicate that auraptene activates PPARgamma in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities.Entities:
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Year: 2007 PMID： 18060855 DOI： 10.1016/j.bbrc.2007.11.119
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575