Literature DB >> 180605

Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus.

A A Like, A A Rossini.   

Abstract

Multiple small injections of streptozotocin in mice produce pancreatic insulitis, with progression to nearly complete beta cell destruction and diabetes mellitus. The timing and appearance of the inflammatory islet lesions suggest but do not prove that streptozotocin acts by initiating a cell-mediated immune reaction. Ultrastructural evidence of abundant type C viruses within beta cells of treated mice suggests that streptozotocin may activate murine leukemia virus in vivo in susceptible hosts.

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Year:  1976        PMID： 180605     DOI： 10.1126/science.180605

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  271 in total

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9.  Down-regulation of multiple low dose streptozotocin-induced diabetes by mycophenolate mofetil.

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10.  Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.

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