Literature DB >> 18058535

Novel S-ribosylhomocysteine analogues as potential inhibitors of LuxS enzyme.

Stanislaw F Wnuk1, Jennifer Lalama, Jenay Robert, Craig A Garmendia.   

Abstract

Selective cross-coupling of the protected 6-fluoro-6-iodo-alpha-D-ribo-hex-5-enofuranose with 2 equivalents of 4-ethoxy-4-oxobutylzinc bromide in the presence of Pd[P(Ph)(3)](4) followed by deprotections gave methyl 5,6,7,8,9-pentadeoxy-6-fluoro-alpha/beta-D-ribo-dec-5(Z)-enofuranuronate; a S-ribosylhomocysteine analogue with the sulfur and carbon-5 atoms replaced by the fluoro(vinyl) unit.

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Year:  2007        PMID: 18058535     DOI: 10.1080/15257770701513190

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  2 in total

1.  A naturally occurring brominated furanone covalently modifies and inactivates LuxS.

Authors:  Tianzhu Zang; Bobby W K Lee; Lisa M Cannon; Kathryn A Ritter; Shujia Dai; Dacheng Ren; Thomas K Wood; Zhaohui Sunny Zhou
Journal:  Bioorg Med Chem Lett       Date:  2009-09-03       Impact factor: 2.823

2.  S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit.

Authors:  Stanislaw F Wnuk; Jennifer Lalama; Craig A Garmendia; Jenay Robert; Jinge Zhu; Dehua Pei
Journal:  Bioorg Med Chem       Date:  2008-03-14       Impact factor: 3.641

  2 in total

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