| Literature DB >> 19775890 |
Tianzhu Zang1, Bobby W K Lee, Lisa M Cannon, Kathryn A Ritter, Shujia Dai, Dacheng Ren, Thomas K Wood, Zhaohui Sunny Zhou.
Abstract
Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).Entities:
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Year: 2009 PMID： 19775890 PMCID： PMC2760616 DOI： 10.1016/j.bmcl.2009.08.095
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823