Literature DB >> 18057133

The microbicide tenofovir does not inhibit nucleic acid amplification tests for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine samples.

Billie Jo Wood1, Patricia Rizzo-Price, Jeff Holden, Andrew Hardick, Thomas C Quinn, Charlotte A Gaydos.   

Abstract

The potential inhibitory effects of tenofovir and a placebo were examined using the Becton Dickinson ProbeTec, Gen-Probe Aptima Combo 2, and Roche Amplicor tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae. Concentrations of 5% to 0% of tenofovir and the placebo were added to dilutions of C. trachomatis and N. gonorrhoeae. No appreciable inhibition was observed.

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Year:  2007        PMID： 18057133      PMCID： PMC2238109          DOI： 10.1128/JCM.01867-07

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  19 in total

Review 1.  Microbicides: a new approach to preventing HIV and other sexually transmitted infections.

Authors:  Alan Stone
Journal:  Nat Rev Drug Discov       Date:  2002-12       Impact factor: 84.694

Review 2.  Microbicides and other topical strategies to prevent vaginal transmission of HIV.

Authors:  Michael M Lederman; Robin E Offord; Oliver Hartley
Journal:  Nat Rev Immunol       Date:  2006-05       Impact factor: 53.106

3.  Microbicides--aids to safer sex.

Authors:  Robin Shattock; Suniti Solomon
Journal:  Lancet       Date:  2004-03-27       Impact factor: 79.321

4.  Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA.

Authors:  K K Van Rompay; M D Miller; M L Marthas; N A Margot; P J Dailey; D R Canfield; R P Tarara; J M Cherrington; N L Aguirre; N Bischofberger; N C Pedersen
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

5.  Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection.

Authors:  K K Van Rompay; M B McChesney; N L Aguirre; K A Schmidt; N Bischofberger; M L Marthas
Journal:  J Infect Dis       Date:  2001-07-16       Impact factor: 5.226

6.  Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.

Authors:  B L Robbins; R V Srinivas; C Kim; N Bischofberger; A Fridland
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

Review 7.  Microbicide drug candidates to prevent HIV infection.

Authors:  Jan Balzarini; Lut Van Damme
Journal:  Lancet       Date:  2007-03-03       Impact factor: 79.321

Review 8.  Urine nucleic acid amplification tests for the diagnosis of sexually transmitted infections in clinical practice.

Authors:  Charlotte A Gaydos; Thomas C Quinn
Journal:  Curr Opin Infect Dis       Date:  2005-02       Impact factor: 4.915

9.  Comparison of three nucleic acid amplification tests for detection of Chlamydia trachomatis in urine specimens.

Authors:  Charlotte A Gaydos; Mellisa Theodore; Nicholas Dalesio; Billie Jo Wood; Thomas C Quinn
Journal:  J Clin Microbiol       Date:  2004-07       Impact factor: 5.948

10.  Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women.

Authors:  Kenneth H Mayer; Lisa A Maslankowski; Fang Gai; Wafaa M El-Sadr; Jessica Justman; Antonia Kwiecien; Benoît Mâsse; Susan H Eshleman; Craig Hendrix; Kathleen Morrow; James F Rooney; Lydia Soto-Torres
Journal:  AIDS       Date:  2006-02-28       Impact factor: 4.177
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  1 in total

1.  Molecular Diagnosis of Sexually Transmitted Chlamydia trachomatis in the United States.

Authors:  April L Harkins; Erik Munson
Journal:  ISRN Obstet Gynecol       Date:  2011-06-12
  1 in total

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