BACKGROUND: The nosological status of auditory hallucinations in non-clinical samples is unclear. AIMS: To investigate the functional neural basis of non-clinical hallucinations. METHOD: After selection from 1206 people, 68 participants of high, medium and low hallucination proneness completed a task designed to elicit verbal hallucinatory phenomena under conditions of stimulus degradation. Eight subjects who reported hearing a voice when none was present repeated the task during functional imaging. RESULTS: During the signal detection task, the high hallucination-prone participants reported a voice to be present when it was not (false alarms) significantly more often than the average or low participants (P<0.03, d.f.=2). On functional magnetic resonance imaging, patterns of activation during these false alarms showed activation in the superior and middle temporal cortex (P<0.001). CONCLUSIONS: Auditory hallucinatory experiences reported in non-clinical samples appear to be mediated by similar patterns of cerebral activation as found during hallucinations in schizophrenia.
BACKGROUND: The nosological status of auditory hallucinations in non-clinical samples is unclear. AIMS: To investigate the functional neural basis of non-clinicalhallucinations. METHOD: After selection from 1206 people, 68 participants of high, medium and low hallucination proneness completed a task designed to elicit verbal hallucinatory phenomena under conditions of stimulus degradation. Eight subjects who reported hearing a voice when none was present repeated the task during functional imaging. RESULTS: During the signal detection task, the high hallucination-prone participants reported a voice to be present when it was not (false alarms) significantly more often than the average or low participants (P<0.03, d.f.=2). On functional magnetic resonance imaging, patterns of activation during these false alarms showed activation in the superior and middle temporal cortex (P<0.001). CONCLUSIONS:Auditory hallucinatory experiences reported in non-clinical samples appear to be mediated by similar patterns of cerebral activation as found during hallucinations in schizophrenia.
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Authors: Vijay A Mittal; Joseph M Orr; Jessica A Turner; Andrea L Pelletier; Derek J Dean; Jessica Lunsford-Avery; Tina Gupta Journal: Schizophr Res Date: 2013-10-22 Impact factor: 4.939
Authors: Vijay A Mittal; Andrew Smolen; Derek J Dean; Andrea L Pelletier; Jessica Lunsford-Avery; Ashley Smith Journal: Schizophr Res Date: 2012-07-04 Impact factor: 4.939
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Authors: Andrea Pelletier-Baldelli; Derek J Dean; Jessica R Lunsford-Avery; Ashley K Smith Watts; Joseph M Orr; Tina Gupta; Zachary B Millman; Vijay A Mittal Journal: Psychiatry Res Date: 2014-04-04 Impact factor: 3.222