BACKGROUND: In low- and middle-income countries people with schizophrenia are reported to experience better outcomes than those in high-income countries. AIMS: To examine structural brain differences in people with first-episode psychosis and controls in Brazil. METHOD: Magnetic resonance imaging using voxel-based morphometry was performed on 122 people with first-episode psychosis and 94 controls. RESULTS: There were significant decreases in grey matter in the left superior temporal and inferior prefrontal cortices, insula bilaterally and the right hippocampal region in first-episode psychosis (P<0.05, corrected for multiple comparisons). The subgroup of people with schizophrenia (n=62) exhibited a similar pattern of decrease in grey matter relative to controls. CONCLUSIONS: Structural abnormalities reported in psychosis in high-income countries are also present in first-episode psychosis in Brazil.
BACKGROUND: In low- and middle-income countries people with schizophrenia are reported to experience better outcomes than those in high-income countries. AIMS: To examine structural brain differences in people with first-episode psychosis and controls in Brazil. METHOD: Magnetic resonance imaging using voxel-based morphometry was performed on 122 people with first-episode psychosis and 94 controls. RESULTS: There were significant decreases in grey matter in the left superior temporal and inferior prefrontal cortices, insula bilaterally and the right hippocampal region in first-episode psychosis (P<0.05, corrected for multiple comparisons). The subgroup of people with schizophrenia (n=62) exhibited a similar pattern of decrease in grey matter relative to controls. CONCLUSIONS:Structural abnormalities reported in psychosis in high-income countries are also present in first-episode psychosis in Brazil.
Authors: Marcus V Zanetti; Maristela S Schaufelberger; Cláudio C de Castro; Paulo R Menezes; Márcia Scazufca; Philip K McGuire; Robin M Murray; Geraldo F Busatto Journal: Br J Psychiatry Date: 2008-07 Impact factor: 9.319
Authors: Taís M Minatogawa-Chang; Maristela S Schaufelberger; Adriana M Ayres; Fábio L S Duran; Elisa K Gutt; Robin M Murray; Teresa M Rushe; Philip K McGuire; Paulo R Menezes; Marcia Scazufca; Geraldo F Busatto Journal: Schizophr Res Date: 2009-07-17 Impact factor: 4.939
Authors: Débora Terribilli; Maristela S Schaufelberger; Fábio L S Duran; Marcus V Zanetti; Pedro K Curiati; Paulo R Menezes; Márcia Scazufca; Edson Amaro; Cláudia C Leite; Geraldo F Busatto Journal: Neurobiol Aging Date: 2009-03-12 Impact factor: 4.673