| Literature DB >> 18054880 |
Hans Wildiers1, Ian Kunkler2, Laura Biganzoli3, Jacques Fracheboud4, George Vlastos5, Chantal Bernard-Marty6, Arti Hurria7, Martine Extermann8, Véronique Girre9, Etienne Brain10, Riccardo A Audisio11, Harry Bartelink12, Mary Barton13, Sharon H Giordano14, Hyman Muss15, Matti Aapro16.
Abstract
Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality in women worldwide. Elderly individuals make up a large part of the breast cancer population, and there are important specific considerations for this population. The International Society of Geriatric Oncology created a task force to assess the available evidence on breast cancer in elderly individuals, and to provide evidence-based recommendations for the diagnosis and treatment of breast cancer in such individuals. A review of the published work was done with the results of a search on Medline for English-language articles published between 1990 and 2007 and of abstracts from key international conferences. Recommendations are given on the topics of screening, surgery, radiotherapy, (neo)adjuvant hormone treatment and chemotherapy, and metastatic disease. Since large randomised trials in elderly patients with breast cancer are scarce, there is little level I evidence for the treatment of such patients. The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults.Entities:
Mesh：
Substances：
Year: 2007 PMID： 18054880 DOI： 10.1016/S1470-2045(07)70378-9
Source DB: PubMed Journal: Lancet Oncol ISSN： 1470-2045 Impact factor: 41.316