Literature DB >> 18054813

Trinucleotide repeats are prevalent among cancer-related genes.

Yael Haberman1, Ninette Amariglio, Gideon Rechavi, Eli Eisenberg.   

Abstract

Trinucleotide repeats (TNRs) have been primarily connected to neurologic and neuromuscular diseases, with few specific TNRs linked with various tumors. Here we conduct a genome-wide analysis and show that TNRs are five times more prevalent in cancer-related human genes. Interestingly, we also find that cancer-related genes are significantly longer than other genes. Our results suggest that genes containing TNRs are more prone to mutagenesis. The database of TNR genes can be used as a list of candidate cancer-related genes.

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Year:  2007        PMID： 18054813     DOI： 10.1016/j.tig.2007.09.005

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  4 in total

Review 1.  Regions of homozygosity and their impact on complex diseases and traits.

Authors:  Chee Seng Ku; Nasheen Naidoo; Shu Mei Teo; Yudi Pawitan
Journal:  Hum Genet       Date:  2010-11-23       Impact factor: 4.132

2.  Environmental stress induces trinucleotide repeat mutagenesis in human cells.

Authors:  Nimrat Chatterjee; Yunfu Lin; Beatriz A Santillan; Patricia Yotnda; John H Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-09       Impact factor: 11.205

3.  Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.

Authors:  Eulàlia Salichs; Alice Ledda; Loris Mularoni; M Mar Albà; Susana de la Luna
Journal:  PLoS Genet       Date:  2009-03-06       Impact factor: 5.917

4.  Triplet repeat length bias and variation in the human transcriptome.

Authors:  Michael Molla; Arthur Delcher; Shamil Sunyaev; Charles Cantor; Simon Kasif
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-17       Impact factor: 11.205
  4 in total

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