Literature DB >> 18054064

Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis.

Amy L Jenkins1, Yang Zhang, Steven E Ealick, Tadhg P Begley.   

Abstract

TenA catalyzes the hydrolysis of 4-amino-5-aminomethyl-2-methylpyrimidine and participates in the salvage of base-degraded thiamin. Here, we describe mutagenesis of the active site of TenA guided by structures of the enzyme complexed to a substrate analog and to the product. Catalytic roles for each of the active site residues are identified and a mechanism for the reaction is described.

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Year:  2007        PMID： 18054064      PMCID： PMC2293645          DOI： 10.1016/j.bioorg.2007.10.005

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  13 in total

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Journal:  J Biol Chem       Date:  1996-02-16       Impact factor: 5.157
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  11 in total

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Authors:  Christopher T Jurgenson; Tadhg P Begley; Steven E Ealick
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10.  Globally Important Haptophyte Algae Use Exogenous Pyrimidine Compounds More Efficiently than Thiamin.

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