Literature DB >> 18052129

Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity.

Kyoko Suzuki1, Mamoru Okasaka, Yoshiki Kashiwada, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K Kodzhimatov, Ozodbek Ashurmetov, Michiko Sekiya, Yasumasa Ikeshiro.   

Abstract

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.

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Year:  2007        PMID： 18052129     DOI： 10.1021/np0703996

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Four new glucosides from the aerial parts of Mediasia macrophylla.

Authors:  Shin-Ichiro Kurimoto; Mamoru Okasaka; Yoshiki Kashiwada; Olimjon K Kodzhimatov; Yoshihisa Takaishi
Journal:  J Nat Med       Date:  2010-07-17       Impact factor: 2.343

2.  Antioxidant and antitumor effects of ferula sinkiangensis K. M. Shen.

Authors:  Haiying Zhang; Jun Lu; Longlong Zhou; Lin Jiang; Mingxin Zhou
Journal:  Int J Clin Exp Med       Date:  2015-11-15

3.  Cytotoxic Activity of Sesquiterpenoids Isolated from Endemic Ferula tenuissima Hub.-Mor & Peşmen.

Authors:  Fadime Aydoğan; Şura Baykan; Bilge Debeleç Bütüner
Journal:  Turk J Pharm Sci       Date:  2019-11-11

4.  8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells.

Authors:  Cui Zhang; Yingnan Jiang; Jin Zhang; Jian Huang; Jinhui Wang
Journal:  Int J Mol Sci       Date:  2015-07-02       Impact factor: 5.923

5.  Bacterial diversity and community structure in the rhizosphere of four Ferula species.

Authors:  Xiuling Wang; Zhongke Wang; Ping Jiang; Yaling He; Yudi Mu; Xinhua Lv; Li Zhuang
Journal:  Sci Rep       Date:  2018-03-28       Impact factor: 4.379

6.  Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors.

Authors:  Tarik A Mohamed; Abdelsamed I Elshamy; Mahmoud A A Ibrahim; Ammar Zellagui; Mahmoud F Moustafa; Alaa H M Abdelrahman; Shinji Ohta; Paul W Pare; Mohamed-Elamir F Hegazy
Journal:  RSC Adv       Date:  2020-09-18       Impact factor: 4.036

7.  Variation of rhizosphere bacterial community diversity in the desert ephemeral plant Ferula sinkiangensis across environmental gradients.

Authors:  Tao Zhang; Zhongke Wang; Xinhua Lv; Hanli Dang; Li Zhuang
Journal:  Sci Rep       Date:  2020-10-28       Impact factor: 4.379

Review 8.  Cytotoxic activity of the genus Ferula (Apiaceae) and its bioactive constituents.

Authors:  Mehrdad Iranshahi; Ramin Rezaee; Mona Najaf Najafi; Ali Haghbin; Jamal Kasaian
Journal:  Avicenna J Phytomed       Date:  2018 Jul-Aug

Review 9.  Phytochemical studies on traditional herbal medicines based on the ethnopharmacological information obtained by field studies.

Authors:  Naonobu Tanaka; Yoshiki Kashiwada
Journal:  J Nat Med       Date:  2021-07-13       Impact factor: 2.343
  9 in total

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