BACKGROUND/ OBJECTIVE: It is generally recommended that patients with chronic viral hepatitis should be vaccinated against hepatitis A virus (HAV) infection. We intended to evaluate the prevalence of IgG anti-HAV according to age in patients chronically infected with hepatitis B virus or hepatitis C virus in Korea. METHODS: From June to October 2006, 303 patients (226 male, 77 female) with chronic hepatitis, liver cirrhosis, or hepatocellular carcinoma were recruited (mean age 50.8+/-14.4 years; range 16-84). The sera were tested for antibodies to HAV, and overall and age-specific seroprevalence of anti-HAV was assessed. RESULTS: Hepatitis B virus infection was the etiology of liver diseases in 267 patients (88.1%), with hepatitis C virus infection in 36 (11.9%). The distribution of clinical diagnosis was chronic hepatitis in 86 patients (28.4%), liver cirrhosis in 36 (11.9%), and hepatocellular carcinoma in 181 (57.9%). The patients were categorized by decade of age and the distribution was as follows: nine patients (2.5%) in their teens, 23 (6.2%) in their 20s, 36 (12.4%) in their 30s, 78 (25.7%) in their 40s, 72 (24.1%) in their 50s, and 85 (29%) >or=61 years. The overall seroprevalence of anti-HAV was 87.8% (266/303), and no difference was observed in sex (86.7 vs. 90.9%, P=0.42). The seroprevalence in each age group was 22.2, 26.1, 72.2, 97.4, 100 and 98.8%, respectively, showing marked increase in those over 40 years of age (P<0.001). CONCLUSION: Our study demonstrates that most Korean patients over 40 years of age with chronic liver disease have already been exposed to HAV.
BACKGROUND/ OBJECTIVE: It is generally recommended that patients with chronic viral hepatitis should be vaccinated against hepatitis A virus (HAV) infection. We intended to evaluate the prevalence of IgG anti-HAV according to age in patients chronically infected with hepatitis B virus or hepatitis C virus in Korea. METHODS: From June to October 2006, 303 patients (226 male, 77 female) with chronic hepatitis, liver cirrhosis, or hepatocellular carcinoma were recruited (mean age 50.8+/-14.4 years; range 16-84). The sera were tested for antibodies to HAV, and overall and age-specific seroprevalence of anti-HAV was assessed. RESULTS:Hepatitis B virus infection was the etiology of liver diseases in 267 patients (88.1%), with hepatitis C virus infection in 36 (11.9%). The distribution of clinical diagnosis was chronic hepatitis in 86 patients (28.4%), liver cirrhosis in 36 (11.9%), and hepatocellular carcinoma in 181 (57.9%). The patients were categorized by decade of age and the distribution was as follows: nine patients (2.5%) in their teens, 23 (6.2%) in their 20s, 36 (12.4%) in their 30s, 78 (25.7%) in their 40s, 72 (24.1%) in their 50s, and 85 (29%) >or=61 years. The overall seroprevalence of anti-HAV was 87.8% (266/303), and no difference was observed in sex (86.7 vs. 90.9%, P=0.42). The seroprevalence in each age group was 22.2, 26.1, 72.2, 97.4, 100 and 98.8%, respectively, showing marked increase in those over 40 years of age (P<0.001). CONCLUSION: Our study demonstrates that most Korean patients over 40 years of age with chronic liver disease have already been exposed to HAV.
Authors: Goh Eun Chung; Jeong Yoon Yim; Donghee Kim; Seon Hee Lim; Min Jung Park; Young Sun Kim; Sun Young Yang; Jong In Yang; Sang-Heon Cho Journal: Gut Liver Date: 2011-03-16 Impact factor: 4.519
Authors: Sang Ho Lee; Hyoung Su Kim; Kwon Oh Park; Jong Won Park; Seung Yeon Chun; Seung Jin Lim; Hyun Jung Cho; Sung Jun Kim; Hye Won Park; Han Kook Moon; Woon Geon Shin; Kyung Ho Kim; Myoung Kuk Jang; Jin Heon Lee; Hak Yang Kim Journal: Korean J Hepatol Date: 2010-12
Authors: A Ahmadi Vasmehjani; D Javeshghani; R Baharlou; M Shayestehpour; S D Mousavinasab; N Joharinia; S E Enderami Journal: Epidemiol Infect Date: 2014-04-17 Impact factor: 4.434
Authors: So Young Kwon; Sang Hoon Park; Jong Eun Yeon; Sook Hyang Jeong; Oh Sang Kwon; Jin Woo Lee; Hong Soo Kim; Yeon Seok Seo; Young Seok Kim; Joo Hyun Sohn; Hyung Joon Yim; Jong Young Choi; Myung Seok Lee; Young Oh Kweon; Jae Youn Cheong; Haak Cheoul Kim; Heon Ju Lee; Soon Koo Baik; Hyonggin An; Kwan Soo Byun Journal: J Korean Med Sci Date: 2014-01-28 Impact factor: 2.153