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Literature DB >> 24742346

Hepatitis A infection in patients with chronic viral liver disease: a cross-sectional study in Jahrom, Iran.

A Ahmadi Vasmehjani¹, D Javeshghani¹, R Baharlou¹, M Shayestehpour², S D Mousavinasab³, N Joharinia¹, S E Enderami⁴.

Abstract

Infection with hepatitis A virus (HAV) in patient with chronic liver disease (CLD; due to hepatitis B or hepatitis C) may cause severe disease and fulminant liver failure. This study aimed to determine the seroprevalence of HAV antibodies in patients infected with HCV or HBV in Iran (Jahrom city). A total of 159 patients with underlying CLD were recruited between September 2012 and February 2013. Serum samples were collected from each patient and tested for anti-HAV using enzyme-linked immunosorbent assay (ELISA). The overall seroprevalence of total anti-HAV was 79·2%. Patients aged 20-30 years had the lowest (28·3%) anti-HAV seropositivity and those aged >50 years had the highest (95%) seropositivity. The overall prevalence of anti-HAV in patients with chronic HCV and HBV infection was 93·7% and 77·1%, respectively. The anti-HAV seropositivity in liver cirrhosis patients was 100% compared to CLD patients. Because of low HAV immunity in younger CLD patients, vaccination against HAV should be considered.

Entities: Chemical

Keywords: ELISA; hepatitis A; hepatitis B; hepatitis C

Mesh：

Substances：
Hepatitis A Antibodies

Year: 2014 PMID： 24742346 PMCID： PMC9507048 DOI： 10.1017/S0950268814000806

Source DB: PubMed Journal: Epidemiol Infect ISSN： 0950-2688 Impact factor: 4.434

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