BACKGROUND: Febrile infections in children with leukemia are common. The occurrence of possible mixed bacterial-viral infections is unknown. METHODS: We searched for viruses in leukemic children with blood culture-positive bacterial infections. The prospective multicenter survey included 156 febrile episodes in 51 children with acute leukemia. The mean follow-up time was 1.5 years per patient (27,743 patient-days at risk). Sixteen viruses were searched for from nasal swab and stool samples using virus culture, virus antigen detection, and polymerase chain reaction tests. RESULTS: Bacterial blood cultures were positive in 19 (11%) febrile episodes among 17 children. In half of the septic episodes (11 of 19), a virus was also found. Rhinovirus and respiratory syncytial virus were the most common viruses detected. CONCLUSIONS: Our findings suggest that invasive bacterial infections are commonly associated with viral infections in children with leukemia.
BACKGROUND:Febrile infections in children with leukemia are common. The occurrence of possible mixed bacterial-viral infections is unknown. METHODS: We searched for viruses in leukemicchildren with blood culture-positive bacterial infections. The prospective multicenter survey included 156 febrile episodes in 51 children with acute leukemia. The mean follow-up time was 1.5 years per patient (27,743 patient-days at risk). Sixteen viruses were searched for from nasal swab and stool samples using virus culture, virus antigen detection, and polymerase chain reaction tests. RESULTS: Bacterial blood cultures were positive in 19 (11%) febrile episodes among 17 children. In half of the septic episodes (11 of 19), a virus was also found. Rhinovirus and respiratory syncytial virus were the most common viruses detected. CONCLUSIONS: Our findings suggest that invasive bacterial infections are commonly associated with viral infections in children with leukemia.
Authors: Philipp Agyeman; Udo Kontny; David Nadal; Kurt Leibundgut; Felix Niggli; Arne Simon; Andreas Kronenberg; Reno Frei; Hugo Escobar; Thomas Kühne; Maja Beck-Popovic; Nicole Bodmer; Roland A Ammann Journal: Pediatr Infect Dis J Date: 2014-09 Impact factor: 2.129
Authors: Eliana C A Benites; Dayane P Cabrini; Andrea C B Silva; Juliana C Silva; Daniel T Catalan; Eitan N Berezin; Maria R A Cardoso; Saulo D Passos Journal: J Pediatr (Rio J) Date: 2014-04-02 Impact factor: 2.197
Authors: Ville Peltola; Tuomas Jartti; Anne Putto-Laurila; Jussi Mertsola; Raija Vainionpää; Matti Waris; Timo Hyypiä; Olli Ruuskanen Journal: J Med Virol Date: 2009-10 Impact factor: 2.327
Authors: Ushanandini Mohanraj; Maija Jokinen; Rajita Rayamajhi Thapa; Minna Paloniemi; Timo Vesikari; Maija Lappalainen; Eveliina Tarkka; Zaiga Nora-Krūkle; Anda Vilmane; Kim Vettenranta; Charles Mangani; Sami Oikarinen; Yue-Mei Fan; Per Ashorn; Elina Väisänen; Maria Söderlund-Venermo Journal: Viruses Date: 2021-03-15 Impact factor: 5.048