Elan D Louis1, Okan Dogu. 1. GH Sergievsky Center, Columbia University, New York, NY, USA. edl2@columbia.edu
Abstract
BACKGROUND/AIMS: The distribution of age of onset of essential tremor (ET) is unclear, with discrepancies in the literature. Some data suggest a bimodal distribution and other data 1 late-life peak. We studied age of ET onset in 2 distinct settings: a population-based study and a tertiary referral center. METHODS: Age of onset data were collected. RESULTS: In the population, there was only a small peak at the age of <or=30 years (14.1% of cases) but a clear peak in later life (85.9% of cases). In the tertiary referral center, a bimodal distribution was apparent with 1 large peak (42.2% of cases) at the age of <or=40 years and the second large peak (57.8% of cases) in later life. Familial cases accounted for only 52.6% of young-onset cases from the population, yet 82.7% from the tertiary center. DISCUSSION: In the population-based study, a peak in later life was clearly present but a young-onset peak was barely discernable, comprising few cases. By contrast, in a tertiary referral center, age of onset was clearly bimodal. While age of ET onset is often said to be bimodal, this may be due to the preferential referral to tertiary centers of patients with young-onset, familial ET. (c) 2007 S. Karger AG, Basel.
BACKGROUND/AIMS: The distribution of age of onset of essential tremor (ET) is unclear, with discrepancies in the literature. Some data suggest a bimodal distribution and other data 1 late-life peak. We studied age of ET onset in 2 distinct settings: a population-based study and a tertiary referral center. METHODS: Age of onset data were collected. RESULTS: In the population, there was only a small peak at the age of <or=30 years (14.1% of cases) but a clear peak in later life (85.9% of cases). In the tertiary referral center, a bimodal distribution was apparent with 1 large peak (42.2% of cases) at the age of <or=40 years and the second large peak (57.8% of cases) in later life. Familial cases accounted for only 52.6% of young-onset cases from the population, yet 82.7% from the tertiary center. DISCUSSION: In the population-based study, a peak in later life was clearly present but a young-onset peak was barely discernable, comprising few cases. By contrast, in a tertiary referral center, age of onset was clearly bimodal. While age of ET onset is often said to be bimodal, this may be due to the preferential referral to tertiary centers of patients with young-onset, familial ET. (c) 2007 S. Karger AG, Basel.
Authors: O Dogu; S Sevim; H Camdeviren; T Sasmaz; R Bugdayci; M Aral; H Kaleagasi; S Un; E D Louis Journal: Neurology Date: 2003-12-23 Impact factor: 9.910
Authors: Lorraine N Clark; Naeun Park; Sergey Kisselev; Eileen Rios; Joseph H Lee; Elan D Louis Journal: Eur J Hum Genet Date: 2010-04-07 Impact factor: 4.246
Authors: Rachel Babij; Michelle Lee; Etty Cortés; Jean-Paul G Vonsattel; Phyllis L Faust; Elan D Louis Journal: Brain Date: 2013-09-12 Impact factor: 13.501
Authors: Sheng-Han Kuo; Jie Wang; William J Tate; Ming-Kai Pan; Geoffrey C Kelly; Jesus Gutierrez; Etty P Cortes; Jean-Paul G Vonsattel; Elan D Louis; Phyllis L Faust Journal: Cerebellum Date: 2017-04 Impact factor: 3.847
Authors: Hreinn Stefansson; Stacy Steinberg; Hjorvar Petursson; Omar Gustafsson; Iris H Gudjonsdottir; Gudrun A Jonsdottir; Stefan T Palsson; Thorlakur Jonsson; Jona Saemundsdottir; Gyda Bjornsdottir; Yvonne Böttcher; Theodora Thorlacius; Dietrich Haubenberger; Alexander Zimprich; Eduard Auff; Christoph Hotzy; Claudia M Testa; Lisa A Miyatake; Ami R Rosen; Kristleifur Kristleifsson; David Rye; Friedrich Asmus; Ludger Schöls; Martin Dichgans; Finnbogi Jakobsson; John Benedikz; Unnur Thorsteinsdottir; Jeffrey Gulcher; Augustine Kong; Kari Stefansson Journal: Nat Genet Date: 2009-02-01 Impact factor: 38.330