Literature DB >> 180430

Relationship between receptor and mammary tumour virus production after stimulation by glucocorticoid.

G Shyamala, C Dickson.   

Abstract

A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various steroids to stimulate MTV is related directly to the retention of the steroid-receptor complex in the nuclei. Progesterone has a high affinity for the cytoplasmic receptor, is not retained by the nuclei and does not stimulate or block the basal level of MTV production. It is, however, quite effective in abolishing the glucocorticoid-mediated stimulation of MTV and thus behaves as an antagonist of glucocorticoid.

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Year:  1976        PMID： 180430     DOI： 10.1038/262107a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  7 in total

1.  Production of unintegrated mouse mammary tumor virus DNA in infected rat hepatoma cells is a secondary action of dexamethasone.

Authors:  G M Ringold; P R Shank; K R Yamamoto
Journal:  J Virol       Date:  1978-04       Impact factor: 5.103

2.  Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells.

Authors:  G M Ringold; P R Shank; H E Varmus; J Ring; K R Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

3.  Hormonal regulation of casein messenger RNA (mRNA).

Authors:  M R Banerjee; P M Terry; S Sakai; F K Lin; R Ganguly
Journal:  In Vitro       Date:  1978-01

4.  Simultaneous occurrence of pregnancylike lobuloalveolar morphogenesis and casein-gene expression in a culture of the whole mammary gland.

Authors:  N Ganguly; R Ganguly; N M Mehta; L R Crump; M R Banerjee
Journal:  In Vitro       Date:  1981-01

5.  Glucocorticoid modulation of casein gene transcription in mouse mammary gland.

Authors:  R Ganguly; N M Mehta; N Ganguly; M R Banerjee
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

6.  Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions.

Authors:  Z Werb
Journal:  J Exp Med       Date:  1978-06-01       Impact factor: 14.307

7.  Does a betaretrovirus infection trigger primary biliary cirrhosis?

Authors:  Lizhe Xu; Zhiwei Shen; Linsheng Guo; Brent Fodera; Adrian Keogh; Ruth Joplin; Barbara O'Donnell; James Aitken; William Carman; James Neuberger; Andrew Mason
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-27       Impact factor: 12.779
  7 in total

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