Literature DB >> 218215

Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells.

G M Ringold, P R Shank, H E Varmus, J Ring, K R Yamamoto.   

Abstract

Rat hepatoma cells infected with mouse mammary tumor virus (MMTV) acquire viral DNA that becomes covalently linked to the cell DNA. Using restriction endonucleases and the DNA transfer procedure of Southern [Southern , E.M. (1975) J. Mol. Biol. 98, 503--517], we have studied the sites in cellular DNA into which MMTV DNA inserts. These experiments indicate that: (i) there are many sites in cell DNA into which MMTV DNA integrates; (ii) the junctions between viral and cellular DNA occur within a limited portion of the viral genome, (iii) clones that contain MMTV DNA do not necessarily produce viral RNA; and (iv) the extent of transcription and glucocorticoid responsiveness of MMTV proviruses may be dependent on the site(s) in cell DNA in which the viral DNA resides.

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Year:  1979        PMID： 218215      PMCID： PMC383010          DOI： 10.1073/pnas.76.2.665

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred mice.

Authors:  V L Morris; E Medeiros; G M Ringold; J M Bishop; H E Varmus
Journal:  J Mol Biol       Date:  1977-07       Impact factor: 5.469

2.  Production of unintegrated mouse mammary tumor virus DNA in infected rat hepatoma cells is a secondary action of dexamethasone.

Authors:  G M Ringold; P R Shank; K R Yamamoto
Journal:  J Virol       Date:  1978-04       Impact factor: 5.103

3.  The arrangement of simian virus 40 sequences in the DNA of transformed cells.

Authors:  M Botchan; W Topp; J Sambrook
Journal:  Cell       Date:  1976-10       Impact factor: 41.582

4.  Mapping of linear and circular forms of mouse mammary tumor virus DNA with restriction endonucleases: evidence for a large specific deletion occurring at high frequency during circularization.

Authors:  P R Shank; J C Cohen; H E Varmus; K R Yamamoto; G M Ringold
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

5.  Mammary tumor virus DNA: a glucocorticoid-responsive transposable element.

Authors:  K R Yamamoto; M R Stallcup; J Ring; G M Ringold
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1978

6.  Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action.

Authors:  G M Ringold; K R Yamamoto; G M Tomkins; M Bishop; H E Varmus
Journal:  Cell       Date:  1975-11       Impact factor: 41.582

7.  Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.

Authors:  G M Ringold; K R Yamamoto; J M Bishop; H E Varmus
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

8.  Infectious DNA of spleen necrosis virus is integrated at a single site in the DNA of chronically infected chicken fibroblasts.

Authors:  N Battula; H M Temin
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

9.  Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA.

Authors:  H A Young; T Y Shih; E M Scolnick; W P Parks
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

10.  Infection of cultured rat hepatoma cells by mouse mammary tumor virus.

Authors:  G M Ringold; R D Cardiff; H E Varmus; K R Yamamoto
Journal:  Cell       Date:  1977-01       Impact factor: 41.582
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  40 in total

1.  Cellular and viral components that mediate glucocorticoid-regulated processing of retroviral envelope proteins.

Authors:  M R Stallcup; J L Corey; R M Bedgood
Journal:  Cell Biophys       Date:  1991 Oct-Dec

2.  Glucocorticoid-dependent complementation of a hepatoma cell variant defective in viral glycoprotein sorting.

Authors:  N J John; D A Bravo; O K Haffar; G L Firestone
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

3.  Model for phase III autografts of epidermal cells cultured on a collagen-proteoglycan biomatrix.

Authors:  D Walker-Jones; C A Reindorf; E Massac; A D Adekile; G L Harmon; A Stanley-Ambrose
Journal:  J Natl Med Assoc       Date:  1989-10       Impact factor: 1.798

4.  Selection of rat hepatoma cells defective in hormone-regulated production of mouse mammary tumor virus RNA.

Authors:  J R Grove; G M Ringold
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

5.  Asymmetric transcription of mouse mammary tumor virus genes in vivo and in vitro.

Authors:  R S Prewitt; L D Washington; M R Stallcup
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

Review 6.  Splitting hares and tortoises: a classification of neuronal immediate early gene transcription based on poised RNA polymerase II.

Authors:  R N Saha; S M Dudek
Journal:  Neuroscience       Date:  2013-05-24       Impact factor: 3.590

7.  Methylation state and DNase I sensitivity of chromatin containing Moloney murine leukemia virus DNA in exogenously infected mouse cells.

Authors:  P E Montandon; F Montandon; H Fan
Journal:  J Virol       Date:  1982-11       Impact factor: 5.103

8.  A comparison of nucleoside (beta-S)triphosphates and nucleoside (gamma-S)triphosphates as suitable substrates for measuring transcription initiation in preparations of cell nuclei.

Authors:  L D Washington; M R Stallcup
Journal:  Nucleic Acids Res       Date:  1982-12-20       Impact factor: 16.971

9.  Proviruses of mouse mammary tumor virus in normal and neoplastic tissues from GR and C3Hf mouse strains.

Authors:  J C Cohen; H E Varmus
Journal:  J Virol       Date:  1980-08       Impact factor: 5.103

10.  Characterization of endogenous and exogenous mouse mammary tumor virus proviral DNA with site-specific molecular clones.

Authors:  B Groner; E Buetti; H Diggelmann; N E Hynes
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103
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