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Literature DB >> 18036554

Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I.

Mordhwaj S Parihar¹, Rafal R Nazarewicz, Erick Kincaid, Urs Bringold, Pedram Ghafourifar.

Abstract

The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions.

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Year: 2007 PMID： 18036554 PMCID： PMC2211368 DOI： 10.1016/j.bbrc.2007.11.056

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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