Literature DB >> 17963719

12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide by increasing intramitochondrial calcium.

Rafal R Nazarewicz1, Woineshet J Zenebe, Arti Parihar, Mordhwaj S Parihar, Michael Vaccaro, Cameron Rink, Chandan K Sen, Pedram Ghafourifar.   

Abstract

12(S)-hydroxyeicosatetraenoic acid (12-HETE) is one of the metabolites of arachidonic acid involved in pathological conditions associated with mitochondria and oxidative stress. The present study tested effects of 12-HETE on mitochondrial functions. In isolated rat heart mitochondria, 12-HETE increases intramitochondrial ionized calcium concentration that stimulates mitochondrial nitric oxide (NO) synthase (mtNOS) activity. mtNOS-derived NO causes mitochondrial dysfunctions by decreasing mitochondrial respiration and transmembrane potential. mtNOS-derived NO also produces peroxynitrite that induces release of cytochrome c and stimulates aggregation of mitochondria. Similarly, in HL-1 cardiac myocytes, 12-HETE increases intramitochondrial calcium and mitochondrial NO, and induces apoptosis. The present study suggests a novel mechanism for 12-HETE toxicity.

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Year:  2007        PMID： 17963719      PMCID： PMC2210014          DOI： 10.1016/j.abb.2007.09.018

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  37 in total

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Authors:  Pedram Ghafourifar; Melinda L Asbury; Sandeep S Joshi; Eric D Kincaid
Journal:  Methods Enzymol       Date:  2005       Impact factor: 1.600

3.  Increased levels of 12(S)-HETE in patients with essential hypertension.

Authors:  D González-Núñez; J Claria; F Rivera; E Poch
Journal:  Hypertension       Date:  2001-02       Impact factor: 10.190

4.  Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation.

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Review 6.  Vascular oxidative stress in Alzheimer disease.

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Authors:  B Beltrán; A Mathur; M R Duchen; J D Erusalimsky; S Moncada
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8.  Hypoxia/reoxygenation of isolated rat heart mitochondria causes cytochrome c release and oxidative stress; evidence for involvement of mitochondrial nitric oxide synthase.

Authors:  Woineshet J Zenebe; Rafal R Nazarewicz; Mordhwaj S Parihar; Pedram Ghafourifar
Journal:  J Mol Cell Cardiol       Date:  2007-06-02       Impact factor: 5.000

9.  Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.

Authors:  Z-G Xu; S-L Li; L Lanting; Y-S Kim; N Shanmugam; M A Reddy; R Natarajan
Journal:  Kidney Int       Date:  2006-02       Impact factor: 10.612

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  26 in total

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Journal:  Infect Immun       Date:  2014-03-31       Impact factor: 3.441

3.  Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I.

Authors:  Mordhwaj S Parihar; Rafal R Nazarewicz; Erick Kincaid; Urs Bringold; Pedram Ghafourifar
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Review 4.  Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke.

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5.  Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.

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6.  Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine.

Authors:  Hans H Dietrich; Dana R Abendschein; Sung Ho Moon; Neema Nayeb-Hashemi; David J Mancuso; Christopher M Jenkins; Kevin M Kaltenbronn; Kendall J Blumer; John Turk; Richard W Gross
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-04-09       Impact factor: 4.733

Review 7.  Eicosanoid signalling pathways in the heart.

Authors:  Christopher M Jenkins; Ari Cedars; Richard W Gross
Journal:  Cardiovasc Res       Date:  2008-12-14       Impact factor: 10.787

8.  12S-hydroxyeicosatetraenoic acid levels link to coronary artery disease in Type 2 diabetic patients.

Authors:  H J Zhang; C H Sun; H Y Kuang; X Y Jiang; H L Liu; W F Hua; Z J Liu; H Zhou; H Sui; R Qi
Journal:  J Endocrinol Invest       Date:  2012-10-22       Impact factor: 4.256

9.  Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model.

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Journal:  Lipids Health Dis       Date:  2010-10-08       Impact factor: 3.876

10.  Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size.

Authors:  Sung Ho Moon; David J Mancuso; Harold F Sims; Xinping Liu; Annie L Nguyen; Kui Yang; Shaoping Guan; Beverly Gibson Dilthey; Christopher M Jenkins; Carla J Weinheimer; Attila Kovacs; Dana Abendschein; Richard W Gross
Journal:  J Biol Chem       Date:  2016-07-23       Impact factor: 5.157
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