OBJECTIVES: We investigated the possible association of rheumatoid arthritis (RA) with single nucleotide polymorphisms (SNP) within the ficolin (FCN) genes. Two SNPs in the FCN1 gene, four SNPs in the FCN2 gene and one SNP in the FCN3 gene were studied. METHODS: The SNPs within the FCN genes were detected by an experimental INNO-LiPA methodology (Innogenetics, Belgium) in a population consisting of 338 RA patients and 595 controls. The significant SNPs were further evaluated in two subpopulations and related to carriage of the human leukocyte antigen-shared epitope (HLA-SE), rheumatoid factor (RF) and the presence of anti-citrullinated protein/peptide antibodies (ACPA). RESULTS: Two SNPs in the FCN1 gene were significantly associated with RA: the A allele rs2989727 was significantly increased in RA patients (67%) compared with controls (60%) (P = 0.002). Also, the frequency of the G allele of rs1071583 was increased in RA patients (68%) compared with controls (61%) (P = 0.003). Analysis of agreement between SNPs suggested strong linkage between rs2989727 and rs1071583. Carriage of a FCN1 SNP was independent of carriage of the HLA-SE, RF status and ACPA positivity. CONCLUSIONS: We describe two linked SNPs in the FCN1 gene that are associated with the development of RA.
OBJECTIVES: We investigated the possible association of rheumatoid arthritis (RA) with single nucleotide polymorphisms (SNP) within the ficolin (FCN) genes. Two SNPs in the FCN1 gene, four SNPs in the FCN2 gene and one SNP in the FCN3 gene were studied. METHODS: The SNPs within the FCN genes were detected by an experimental INNO-LiPA methodology (Innogenetics, Belgium) in a population consisting of 338 RApatients and 595 controls. The significant SNPs were further evaluated in two subpopulations and related to carriage of the human leukocyte antigen-shared epitope (HLA-SE), rheumatoid factor (RF) and the presence of anti-citrullinated protein/peptide antibodies (ACPA). RESULTS: Two SNPs in the FCN1 gene were significantly associated with RA: the A allele rs2989727 was significantly increased in RApatients (67%) compared with controls (60%) (P = 0.002). Also, the frequency of the G allele of rs1071583 was increased in RApatients (68%) compared with controls (61%) (P = 0.003). Analysis of agreement between SNPs suggested strong linkage between rs2989727 and rs1071583. Carriage of a FCN1 SNP was independent of carriage of the HLA-SE, RF status and ACPA positivity. CONCLUSIONS: We describe two linked SNPs in the FCN1 gene that are associated with the development of RA.
Authors: Angelica B W Boldt; Maria Iolanda N Sanchez; Ewalda R S Stahlke; Rudi Steffensen; Steffen Thiel; Jens C Jensenius; Flávia Costa Prevedello; Marcelo Távora Mira; Jürgen F J Kun; Iara J T Messias-Reason Journal: J Clin Immunol Date: 2012-09-01 Impact factor: 8.317
Authors: C G Ammitzboll; S Thiel; T Ellingsen; B Deleuran; Anette Jorgensen; J C Jensenius; K Stengaard-Pedersen Journal: Rheumatol Int Date: 2011-04-03 Impact factor: 2.631
Authors: Zilma Pereira Dos Anjosa; Manuella Maria Silva Santos; Natassia Javorski Rodrigues; Glaucia Alyne Nunes De Lacerda; Jaqueline Araujo; Jaqueline De Azevêdo Silva; Nathália De Alencar Cunha Tavares; Rafael Lima Guimarães; Sergio Crovella; Lucas André Cavalcanti Brandão Journal: J Genet Date: 2016-12 Impact factor: 1.166
Authors: Don H Anderson; Monte J Radeke; Natasha B Gallo; Ethan A Chapin; Patrick T Johnson; Christy R Curletti; Lisa S Hancox; Jane Hu; Jessica N Ebright; Goldis Malek; Michael A Hauser; Catherine Bowes Rickman; Dean Bok; Gregory S Hageman; Lincoln V Johnson Journal: Prog Retin Eye Res Date: 2009-12-02 Impact factor: 21.198
Authors: J M Ruskamp; M O Hoekstra; D S Postma; M Kerkhof; R W Bottema; G H Koppelman; M M Rovers; A H Wijga; J C de Jongste; B Brunekreef; E A M Sanders Journal: Clin Exp Immunol Date: 2009-03 Impact factor: 4.330
Authors: Paola R Luz; Angelica B W Boldt; Caroline Grisbach; Jürgen F J Kun; Thirumalaisamy P Velavan; Iara J T Messias-Reason Journal: PLoS One Date: 2013-04-04 Impact factor: 3.240