| Literature DB >> 18029175 |
Richard L Mackman1, Constantine G Boojamra, Vidya Prasad, Lijun Zhang, Kuei-Ying Lin, Oleg Petrakovsky, Darius Babusis, James Chen, Janet Douglas, Deborah Grant, Hon C Hui, Choung U Kim, David Y Markevitch, Jennifer Vela, Adrian Ray, Tomas Cihlar.
Abstract
A series of nucleoside phosphonate reverse transcriptase (RT) inhibitors have been synthesized and their anti-HIV activity and resistance profiles evaluated. The most potent analog [5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (d4AP) demonstrated a HIV EC(50)=2.1 microM, and the most favorable resistance profile against HIV-1 variants with K65R, M184V or multiple thymidine analog mutations in RT.Entities:
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Year: 2007 PMID： 18029175 DOI： 10.1016/j.bmcl.2007.10.038
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823