| Literature DB >> 18029173 |
Ryuji Hayashi1, Xiaomin Jin, Gregory R Cook.
Abstract
A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.Entities:
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Year: 2007 PMID： 18029173 PMCID： PMC2574968 DOI： 10.1016/j.bmcl.2007.10.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823