Literature DB >> 18029050

Cell therapy for spinal cord regeneration.

Stephanie M Willerth1, Shelly E Sakiyama-Elbert.   

Abstract

This review presents a summary of the various types of cellular therapy used to treat spinal cord injury. The inhibitory environment and loss of axonal connections after spinal cord injury pose many obstacles to regenerating the lost tissue. Cellular therapy provides a means of restoring the cells lost to the injury and could potentially promote functional recovery after such injuries. A wide range of cell types have been investigated for such uses and the advantages and disadvantages of each cell type are discussed along with the research studying each cell type. Additionally, methods of delivering cells to the injury site are evaluated. Based on the current research, suggestions are given for future investigation of cellular therapies for spinal cord regeneration.

Entities:  

Mesh：

Year:  2007        PMID： 18029050      PMCID： PMC2225623          DOI： 10.1016/j.addr.2007.08.028

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  122 in total

1.  Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord.

Authors:  T Imaizumi; K L Lankford; J D Kocsis
Journal:  Brain Res       Date:  2000-01-31       Impact factor: 3.252

Review 2.  Nogo-A, a potent inhibitor of neurite outgrowth and regeneration.

Authors:  A B Huber; M E Schwab
Journal:  Biol Chem       Date:  2000 May-Jun       Impact factor: 3.915

3.  Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation.

Authors:  S Liu; Y Qu; T J Stewart; M J Howard; S Chakrabortty; T F Holekamp; J W McDonald
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

4.  Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord.

Authors:  J W McDonald; X Z Liu; Y Qu; S Liu; S K Mickey; D Turetsky; D I Gottlieb; D W Choi
Journal:  Nat Med       Date:  1999-12       Impact factor: 53.440

5.  In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP.

Authors:  W Deng; M Obrocka; I Fischer; D J Prockop
Journal:  Biochem Biophys Res Commun       Date:  2001-03-23       Impact factor: 3.575

6.  Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.

Authors:  M S Chen; A B Huber; M E van der Haar; M Frank; L Schnell; A A Spillmann; F Christ; M E Schwab
Journal:  Nature       Date:  2000-01-27       Impact factor: 49.962

7.  Adult bone marrow stromal cells differentiate into neural cells in vitro.

Authors:  J Sanchez-Ramos; S Song; F Cardozo-Pelaez; C Hazzi; T Stedeford; A Willing; T B Freeman; S Saporta; W Janssen; N Patel; D R Cooper; P R Sanberg
Journal:  Exp Neurol       Date:  2000-08       Impact factor: 5.330

8.  Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord.

Authors:  T Kato; O Honmou; T Uede; K Hashi; J D Kocsis
Journal:  Glia       Date:  2000-05       Impact factor: 7.452

9.  Contrasting effects of collagen and bFGF-2 on neural cell function in degradable synthetic PEG hydrogels.

Authors:  Melissa J Mahoney; Kristi S Anseth
Journal:  J Biomed Mater Res A       Date:  2007-05       Impact factor: 4.396

10.  Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia.

Authors:  A Ramón-Cueto; M I Cordero; F F Santos-Benito; J Avila
Journal:  Neuron       Date:  2000-02       Impact factor: 17.173
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  25 in total

1.  Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers.

Authors:  Brian A Aguado; Widya Mulyasasmita; James Su; Kyle J Lampe; Sarah C Heilshorn
Journal:  Tissue Eng Part A       Date:  2011-12-20       Impact factor: 3.845

2.  Nanofiber matrices promote the neuronal differentiation of human embryonic stem cell-derived neural precursors in vitro.

Authors:  Vasiliki Mahairaki; Shawn H Lim; Gregory T Christopherson; Leyan Xu; Igor Nasonkin; Christopher Yu; Hai-Quan Mao; Vassilis E Koliatsos
Journal:  Tissue Eng Part A       Date:  2010-12-18       Impact factor: 3.845

Review 3.  Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells.

Authors:  D Garbossa; M Boido; M Fontanella; C Fronda; A Ducati; A Vercelli
Journal:  Neurosurg Rev       Date:  2012-04-27       Impact factor: 3.042

4.  Two-component protein-engineered physical hydrogels for cell encapsulation.

Authors:  Cheryl T S Wong Po Foo; Ji Seok Lee; Widya Mulyasasmita; Andreina Parisi-Amon; Sarah C Heilshorn
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-10       Impact factor: 11.205

Review 5.  Biomaterial design strategies for the treatment of spinal cord injuries.

Authors:  Karin S Straley; Cheryl Wong Po Foo; Sarah C Heilshorn
Journal:  J Neurotrauma       Date:  2010-01       Impact factor: 5.269

Review 6.  Locomotor dysfunction and pain: the scylla and charybdis of fiber sprouting after spinal cord injury.

Authors:  Ronald Deumens; Elbert A J Joosten; Stephen G Waxman; Bryan C Hains
Journal:  Mol Neurobiol       Date:  2008-04-15       Impact factor: 5.590

7.  Controlled release of glial cell line-derived neurotrophic factor from poly(ε-caprolactone) microspheres.

Authors:  Andrew Agbay; Nima Khadem Mohtaram; Stephanie Michelle Willerth
Journal:  Drug Deliv Transl Res       Date:  2014-04       Impact factor: 4.617

8.  Positively Charged Oligo[Poly(Ethylene Glycol) Fumarate] Scaffold Implantation Results in a Permissive Lesion Environment after Spinal Cord Injury in Rat.

Authors:  Jeffrey S Hakim; Melika Esmaeili Rad; Peter J Grahn; Bingkun K Chen; Andrew M Knight; Ann M Schmeichel; Nasro A Isaq; Mahrokh Dadsetan; Michael J Yaszemski; Anthony J Windebank
Journal:  Tissue Eng Part A       Date:  2015-07       Impact factor: 3.845

9.  Evaluation of the Effect of NT-3 and Biodegradable Poly-L-lactic Acid Nanofiber Scaffolds on Differentiation of Rat Hair Follicle Stem Cells into Neural Cells In Vitro.

Authors:  Fatemeh Moghani Ghoroghi; Leila Beygom Hejazian; Banafshe Esmaielzade; Masumeh Dodel; Masoud Roudbari; Maliheh Nobakht
Journal:  J Mol Neurosci       Date:  2013-08-20       Impact factor: 3.444

10.  Effects of long-term FK506 administration on functional and histopathological outcome after spinal cord injury in adult rat.

Authors:  Kamila Saganová; Judita Orendácová; Igor Sulla; Peter Filipcík; Dása Cízková; Ivo Vanický
Journal:  Cell Mol Neurobiol       Date:  2009-04-07       Impact factor: 5.046
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