Literature DB >> 10756071

Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord.

T Kato1, O Honmou, T Uede, K Hashi, J D Kocsis.   

Abstract

Human olfactory ensheathing cells (OECs) were prepared from adult human olfactory nerves, which were removed during surgery for frontal base tumors, and were transplanted into the demyelinated spinal cord of immunosuppressed adult rats. Extensive remyelination was observed in the lesion site: In situ hybridization using a human DNA probe (COT-1) indicated a similar number of COT-1-positive cells and OEC nuclei within the repaired lesion. The myelination was of a peripheral type with large nuclei and cytoplasmic regions surrounding the axons, characteristic of Schwann cell and OEC remyelination. These results provide evidence that adult human OECs are able to produce Schwann cell-like myelin sheaths around demyelinated axons in the adult mammalian CNS in vivo.

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Year:  2000        PMID： 10756071      PMCID： PMC2605375          DOI： 10.1002/(sici)1098-1136(200005)30:3<209::aid-glia1>3.0.co;2-8

Source DB:  PubMed          Journal:  Glia        ISSN： 0894-1491            Impact factor:   7.452


  45 in total

1.  Cultures of ensheathing cells from neonatal rat olfactory bulbs.

Authors:  M I Chuah; C Au
Journal:  Brain Res       Date:  1993-01-22       Impact factor: 3.252

2.  Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat.

Authors:  D A Utzschneider; D R Archer; J D Kocsis; S G Waxman; I D Duncan
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

3.  Concurrent isolation and characterization of oligodendrocytes, microglia and astrocytes from adult human spinal cord.

Authors:  S R Whittemore; H R Sanon; P M Wood
Journal:  Int J Dev Neurosci       Date:  1993-12       Impact factor: 2.457

4.  Regeneration into the spinal cord of transected dorsal root axons is promoted by ensheathing glia transplants.

Authors:  A Ramón-Cueto; M Nieto-Sampedro
Journal:  Exp Neurol       Date:  1994-06       Impact factor: 5.330

5.  Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells.

Authors:  A K Groves; S C Barnett; R J Franklin; A J Crang; M Mayer; W F Blakemore; M Noble
Journal:  Nature       Date:  1993-04-01       Impact factor: 49.962

6.  Myelination by cryopreserved xenografts and allografts in the myelin-deficient rat.

Authors:  D R Archer; S Levén; I D Duncan
Journal:  Exp Neurol       Date:  1994-02       Impact factor: 5.330

7.  Studies of myelin formation after transplantation of human Schwann cells into the severe combined immunodeficient mouse.

Authors:  A D Levi; R P Bunge
Journal:  Exp Neurol       Date:  1994-11       Impact factor: 5.330

8.  Purification of olfactory nerve ensheathing cells from the olfactory bulb.

Authors:  S C Barnett; A M Hutchins; M Noble
Journal:  Dev Biol       Date:  1993-02       Impact factor: 3.582

9.  The use of xenografting to evaluate the remyelinating potential of glial cell cultures.

Authors:  M P Targett; W F Blakemore
Journal:  Eye (Lond)       Date:  1994       Impact factor: 3.775

Review 10.  Requirements for Schwann cell migration within CNS environments: a viewpoint.

Authors:  R J Franklin; W F Blakemore
Journal:  Int J Dev Neurosci       Date:  1993-10       Impact factor: 2.457
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  43 in total

1.  LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord.

Authors:  J G Boyd; J Lee; V Skihar; R Doucette; M D Kawaja
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-05       Impact factor: 11.205

2.  Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin.

Authors:  Masanori Sasaki; Karen L Lankford; Micheas Zemedkun; Jeffery D Kocsis
Journal:  J Neurosci       Date:  2004-09-29       Impact factor: 6.167

Review 3.  Stem cell transplantation in multiple sclerosis: current status and future prospects.

Authors:  Gianvito Martino; Robin J M Franklin; Anne Baron Van Evercooren; Douglas A Kerr
Journal:  Nat Rev Neurol       Date:  2010-04-20       Impact factor: 42.937

Review 4.  Cell therapy in demyelinating diseases.

Authors:  Claire Rice; Christopher Halfpenny; Neil Scolding
Journal:  NeuroRx       Date:  2004-10

5.  Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells.

Authors:  Mary A Dombrowski; Masanori Sasaki; Karen L Lankford; Jeffery D Kocsis; Christine Radtke
Journal:  Brain Res       Date:  2006-11-16       Impact factor: 3.252

6.  Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat.

Authors:  T Honma; O Honmou; S Iihoshi; K Harada; K Houkin; H Hamada; J D Kocsis
Journal:  Exp Neurol       Date:  2005-06-20       Impact factor: 5.330

7.  Remyelination of spinal cord axons by olfactory ensheathing cells and Schwann cells derived from a transgenic rat expressing alkaline phosphatase marker gene.

Authors:  Yukinori Akiyama; Karen Lankford; Christine Radtke; Charles A Greer; Jeffery D Kocsis
Journal:  Neuron Glia Biol       Date:  2004-02

8.  OEG implantation and step training enhance hindlimb-stepping ability in adult spinal transected rats.

Authors:  Marc D Kubasak; Devin L Jindrich; Hui Zhong; Aya Takeoka; Kimberly C McFarland; Cintia Muñoz-Quiles; Roland R Roy; V Reggie Edgerton; Almudena Ramón-Cueto; Patricia E Phelps
Journal:  Brain       Date:  2007-12-03       Impact factor: 13.501

9.  Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord.

Authors:  Masanori Sasaki; Joel A Black; Karen L Lankford; Hajime A Tokuno; Stephen G Waxman; Jeffery D Kocsis
Journal:  J Neurosci       Date:  2006-02-08       Impact factor: 6.167

10.  Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord.

Authors:  Michio Inoue; Osamu Honmou; Shinichi Oka; Kiyohiro Houkin; Kazuo Hashi; Jeffery D Kocsis
Journal:  Glia       Date:  2003-11       Impact factor: 7.452
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