| Literature DB >> 180270 |
R L Hayes, L C Washburn, B W Wieland, T T Sun, R R Turtle, T A Butler.
Abstract
Carboxyl-labeled 11C-1-aminocyclopentanecarboxylic acid (11C-ACPC) has been prepared in multimillicurie amounts. The conversion of H11CN to 11C-ACPC (t1/2 = 20.4 min) was accomplished by a rapid (20-min) two-step high-temperature modification of the Bücherer-Strecker amino acid synthesis technique, which should be applicable at other accelerator installations. Purification was by ion exchange techniques. Animal studies have indicated that 11C-ACPC is a potential tumor-localizing agent for detecting cancer in humans by nuclear medicine scanning techniques.Entities:
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Year: 1976 PMID： 180270
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057