Literature DB >> 18026288

Diagnostic cellular organization features extracted from autofluorescence images.

Jonathan M Levitt1, Martin Hunter, Claudia Mujat, Margaret McLaughlin-Drubin, Karl Münger, Irene Georgakoudi.   

Abstract

Depth-resolved NADH autofluorescence images are shown to differentiate between normal and precancerous engineered tissues. An inverse power law behavior of the power spectral density (PSD) of these images is observed, indicating a self-affine organization of mitochondrial NADH at length scales 1-10 microm. Power exponents of the PSD functions vary significantly with tissue depth and precancerous state, giving insight into the morphological changes associated with precancerous lesions and providing substantial potential for noninvasive clinical diagnosis of squamous epithelial lesions and tumors.

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Year:  2007        PMID： 18026288     DOI： 10.1364/ol.32.003305

Source DB:  PubMed          Journal:  Opt Lett        ISSN： 0146-9592            Impact factor:   3.776


  21 in total

1.  Semi-automatic quantification of neurite fasciculation in high-density neurite images by the neurite directional distribution analysis (NDDA).

Authors:  Amy M Hopkins; Brandon Wheeler; Cristian Staii; David L Kaplan; Timothy J Atherton
Journal:  J Neurosci Methods       Date:  2014-03-25       Impact factor: 2.390

2.  The potential of label-free nonlinear optical molecular microscopy to non-invasively characterize the viability of engineered human tissue constructs.

Authors:  Leng-Chun Chen; William R Lloyd; Shiuhyang Kuo; Hyungjin Myra Kim; Cynthia L Marcelo; Stephen E Feinberg; Mary-Ann Mycek
Journal:  Biomaterials       Date:  2014-05-20       Impact factor: 12.479

3.  Improved Fourier-based characterization of intracellular fractal features.

Authors:  Joanna Xylas; Kyle P Quinn; Martin Hunter; Irene Georgakoudi
Journal:  Opt Express       Date:  2012-10-08       Impact factor: 3.894

4.  Rapid quantification of pixel-wise fiber orientation data in micrographs.

Authors:  Kyle P Quinn; Irene Georgakoudi
Journal:  J Biomed Opt       Date:  2013-04       Impact factor: 3.170

5.  Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer development.

Authors:  Joanna Xylas; Antonio Varone; Kyle P Quinn; Dimitra Pouli; Margaret E McLaughlin-Drubin; Hong-Thao Thieu; Maria L Garcia-Moliner; Michael House; Martin Hunter; Karl Munger; Irene Georgakoudi
Journal:  Int J Cancer       Date:  2014-06-05       Impact factor: 7.396

Review 6.  Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD.

Authors:  Olivia I Kolenc; Kyle P Quinn
Journal:  Antioxid Redox Signal       Date:  2018-01-30       Impact factor: 8.401

7.  Quantitative characterization of mineralized silk film remodeling during long-term osteoblast-osteoclast co-culture.

Authors:  Rebecca S Hayden; Kyle P Quinn; Carlo A Alonzo; Irene Georgakoudi; David L Kaplan
Journal:  Biomaterials       Date:  2014-01-29       Impact factor: 12.479

8.  Light scattering measurements of subcellular structure provide noninvasive early detection of chemotherapy-induced apoptosis.

Authors:  Kevin J Chalut; Julie Hanson Ostrander; Michael G Giacomelli; Adam Wax
Journal:  Cancer Res       Date:  2009-01-13       Impact factor: 12.701

9.  Two-photon microscopy for non-invasive, quantitative monitoring of stem cell differentiation.

Authors:  William L Rice; David L Kaplan; Irene Georgakoudi
Journal:  PLoS One       Date:  2010-04-16       Impact factor: 3.240

10.  Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease.

Authors:  Lauren M Baugh; Zhiyi Liu; Kyle P Quinn; Sam Osseiran; Conor L Evans; Gordon S Huggins; Philip W Hinds; Lauren D Black; Irene Georgakoudi
Journal:  Nat Biomed Eng       Date:  2017-11-06       Impact factor: 25.671
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