| Literature DB >> 18026102 |
Stephan A Kaeser1, Martin C Herzig, Janaky Coomaraswamy, Ellen Kilger, Maj-Linda Selenica, David T Winkler, Matthias Staufenbiel, Efrat Levy, Anders Grubb, Mathias Jucker.
Abstract
The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.Entities:
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Year: 2007 PMID： 18026102 DOI： 10.1038/ng.2007.23
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330