OBJECTIVES: To discuss the current knowledge on induction, production, sustenance and promotion of neuroendocrine differentiation in human prostate cancer. METHODS: Review of the literature using PubMed search and scientific journal publications. RESULTS: Morphological evidence explains some functional relationship between neuroendocrine and neoplastic surrounding cells. Transdifferentiation phenomenon and new biochemical pathways could be included in the development of androgen independence and prostate cancer progression. CONCLUSION: Multiple evidence seems to confirm that a synergistic functional network between epithelial PSA secretory cells and neuroendocrine intraprostatic system is the main trigger for the induction and sustenance of neuroendocrine differentiation. The development of new antineoplastic molecules should consider the multiple interference of the intercellular network. (c) 2007 S. Karger AG, Basel.
OBJECTIVES: To discuss the current knowledge on induction, production, sustenance and promotion of neuroendocrine differentiation in humanprostate cancer. METHODS: Review of the literature using PubMed search and scientific journal publications. RESULTS: Morphological evidence explains some functional relationship between neuroendocrine and neoplastic surrounding cells. Transdifferentiation phenomenon and new biochemical pathways could be included in the development of androgen independence and prostate cancer progression. CONCLUSION: Multiple evidence seems to confirm that a synergistic functional network between epithelial PSA secretory cells and neuroendocrine intraprostatic system is the main trigger for the induction and sustenance of neuroendocrine differentiation. The development of new antineoplastic molecules should consider the multiple interference of the intercellular network. (c) 2007 S. Karger AG, Basel.
Authors: Chunxiao Wu; Alexander W Wyatt; Anna V Lapuk; Andrew McPherson; Brian J McConeghy; Robert H Bell; Shawn Anderson; Anne Haegert; Sonal Brahmbhatt; Robert Shukin; Fan Mo; Estelle Li; Ladan Fazli; Antonio Hurtado-Coll; Edward C Jones; Yaron S Butterfield; Faraz Hach; Fereydoun Hormozdiari; Iman Hajirasouliha; Paul C Boutros; Robert G Bristow; Steven Jm Jones; Martin Hirst; Marco A Marra; Christopher A Maher; Arul M Chinnaiyan; S Cenk Sahinalp; Martin E Gleave; Stanislav V Volik; Colin C Collins Journal: J Pathol Date: 2012-03-21 Impact factor: 7.996
Authors: David T Ting; Doron Lipson; Suchismita Paul; Brian W Brannigan; Sara Akhavanfard; Erik J Coffman; Gianmarco Contino; Vikram Deshpande; A John Iafrate; Stan Letovsky; Miguel N Rivera; Nabeel Bardeesy; Shyamala Maheswaran; Daniel A Haber Journal: Science Date: 2011-01-13 Impact factor: 47.728
Authors: Jianfei Qi; Koh Nakayama; Robert D Cardiff; Alexander D Borowsky; Karen Kaul; Roy Williams; Stan Krajewski; Dan Mercola; Philip M Carpenter; David Bowtell; Ze'ev A Ronai Journal: Cancer Cell Date: 2010-07-13 Impact factor: 31.743
Authors: Pinar Uysal-Onganer; Yoshiaki Kawano; Mercedes Caro; Marjorie M Walker; Soraya Diez; R Siobhan Darrington; Jonathan Waxman; Robert M Kypta Journal: Mol Cancer Date: 2010-03-10 Impact factor: 27.401