Literature DB >> 18024859

Germline pharmacogenetics of tamoxifen response: have we learned enough?

Zeruesenay Desta, David A Flockhart.   

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Year:  2007        PMID: 18024859      PMCID: PMC2764520          DOI: 10.1200/JCO.2007.13.4957

Source DB:  PubMed          Journal:  J Clin Oncol        ISSN: 0732-183X            Impact factor:   44.544


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2.  Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile.

Authors:  E A Lien; E Solheim; S Kvinnsland; P M Ueland
Journal:  Cancer Res       Date:  1988-04-15       Impact factor: 12.701

3.  A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.

Authors:  V C Jordan; M M Collins; L Rowsby; G Prestwich
Journal:  J Endocrinol       Date:  1977-11       Impact factor: 4.286

4.  Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.

Authors:  Vered Stearns; Michael D Johnson; James M Rae; Alan Morocho; Antonella Novielli; Pankaj Bhargava; Daniel F Hayes; Zeruesenay Desta; David A Flockhart
Journal:  J Natl Cancer Inst       Date:  2003-12-03       Impact factor: 13.506

5.  Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen.

Authors:  D W Robertson; J A Katzenellenbogen; D J Long; E A Rorke; B S Katzenellenbogen
Journal:  J Steroid Biochem       Date:  1982-01       Impact factor: 4.292

6.  Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen.

Authors:  Michael D Johnson; Hong Zuo; Kyung-Hoon Lee; Joseph P Trebley; James Michael Rae; Ross V Weatherman; Zeruesanay Desta; David A Flockhart; Todd C Skaar
Journal:  Breast Cancer Res Treat       Date:  2004-05       Impact factor: 4.872

7.  Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

Authors:  E Coezy; J L Borgna; H Rochefort
Journal:  Cancer Res       Date:  1982-01       Impact factor: 12.701

8.  Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes.

Authors:  Werner Schroth; Lydia Antoniadou; Peter Fritz; Matthias Schwab; Thomas Muerdter; Ulrich M Zanger; Wolfgang Simon; Michel Eichelbaum; Hiltrud Brauch
Journal:  J Clin Oncol       Date:  2007-11-20       Impact factor: 44.544

Review 9.  Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance.

Authors:  V C Jordan
Journal:  Breast Cancer Res Treat       Date:  1982       Impact factor: 4.872

10.  Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.

Authors:  Zeruesenay Desta; Bryan A Ward; Nadia V Soukhova; David A Flockhart
Journal:  J Pharmacol Exp Ther       Date:  2004-05-24       Impact factor: 4.030

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3.  CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark.

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Review 5.  Genotype-guided tamoxifen therapy: time to pause for reflection?

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Review 7.  Clinically available pharmacogenomics tests.

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9.  Tailoring adjuvant endocrine therapy for postmenopausal breast cancer: a CYP2D6 multiple-genotype-based modeling analysis and validation.

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Journal:  PLoS One       Date:  2010-12-20       Impact factor: 3.240

10.  Lack of association between oestrogen receptor polymorphisms and change in bone mineral density with tamoxifen therapy.

Authors:  N L Henry; A Nguyen; F Azzouz; L Li; J Robarge; S Philips; D Cao; T C Skaar; J M Rae; A M Storniolo; D A Flockhart; D F Hayes; V Stearns
Journal:  Br J Cancer       Date:  2009-12-01       Impact factor: 7.640

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