Literature DB >> 18023491

Phantom and in-vivo measurements of dose exposure by image-guided radiotherapy (IGRT): MV portal images vs. kV portal images vs. cone-beam CT.

Cornelia Walter1, Judit Boda-Heggemann, Hansjörg Wertz, Iris Loeb, Angelika Rahn, Frank Lohr, Frederik Wenz.   

Abstract

PURPOSE: Positioning verification is usually performed with treatment beam (MV) portal images (PI) using an electronic portal imaging device (EPID). A new alternative is the use of a low energy photon source (kV) and an additional EPID mounted to the accelerator gantry. This system may be used for PI or--with rotating gantry--as cone-beam CT (CBCT). The dose delivered to the patient by different imaging processes was measured. METHODS AND MATERIALS: A total of 15 in-vivo dose measurements were done in five patients receiving prostate IMRT. For anterior-posterior (AP) and lateral PI with MV and kV photons measurement points were inside the rectum and at the patient's skin. Dose for CBCT was measured in the rectum. Additional measurements for CBCT were done in a cylindrical CT-dose-index (CTDI) phantom to determine peripheral, central and weighted CTDI.
RESULTS: The dose for AP MV PI was 57.8 mGy at the surface and 33.9 mGy in the rectum, for lateral MV PI 69.4 mGy and 31.7 mGy, respectively (5 MU/exposure). The dose for AP kV PI was 0.8 mGy at the surface and 0.2 mGy in the rectum, for lateral PI 1.1 mGy and 0. 1 mGy, respectively. For a CBCT the rectal dose was 17.2 mGy. The peripheral CTDI was 23.6 mGy and the center dose was 10.2 mGy, resulting in a weighted CTDI of 19.1 mGy in the phantom and an estimated surface dose of < or =28 mGy.
CONCLUSIONS: Even taking into account an RBE (Relative Biological Effectiveness) of 2 for kV vs. MV radiation, for kV PI the delivered dose is lower and image quality is better than for MV PI. CBCT provides a 3D-image dataset and dose exposure for one scan is lower than for two MV PI, thus rendering frequent volume imaging during a fractionated course of radiotherapy possible.

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Year:  2007        PMID: 18023491     DOI: 10.1016/j.radonc.2007.10.014

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN: 0167-8140            Impact factor:   6.280


  33 in total

1.  [Image-guided radiation therapy].

Authors:  J Boda-Heggemann; M Guckenberger; U Ganswindt; C Belka; H Wertz; M Blessing; F Wenz; M Fuss; F Lohr
Journal:  Radiologe       Date:  2012-03       Impact factor: 0.635

2.  Electronic portal imaging vs kilovoltage imaging in fiducial marker image-guided radiotherapy for prostate cancer: an analysis of set-up uncertainties.

Authors:  S Gill; J Thomas; C Fox; T Kron; A Thompson; S Chander; S Williams; K H Tai; G Duchesne; F Foroudi
Journal:  Br J Radiol       Date:  2011-10-05       Impact factor: 3.039

3.  Phantom measurements to quantify the accuracy of a commercially available cone-beam CT gray-value matching algorithm using multiple Fiducials.

Authors:  Frederick Marc Köhler; Judit Boda-Heggemann; Beate Küpper; Dirk Wolff; Hansjörg Wertz; Frank Lohr; Frederik Wenz
Journal:  Strahlenther Onkol       Date:  2009-02-18       Impact factor: 3.621

4.  Use of planar kV vs. CBCT in evaluation of setup errors in oesophagus carcinoma radiotherapy.

Authors:  Liliana Martins; Jose Guilherme Couto; Barbara Barbosa
Journal:  Rep Pract Oncol Radiother       Date:  2015-11-14

Review 5.  kV cone-beam CT-based IGRT: a clinical review.

Authors:  Judit Boda-Heggemann; Frank Lohr; Frederik Wenz; Michael Flentje; Matthias Guckenberger
Journal:  Strahlenther Onkol       Date:  2011-04-26       Impact factor: 3.621

6.  Modern radiotherapy using image guidance for unresectable non-small cell lung cancer can improve outcomes in patients treated with chemoradiation therapy.

Authors:  Matthew P Deek; Sinae Kim; Ning Yue; Rekha Baby; Inaya Ahmed; Wei Zou; John Langenfeld; Joseph Aisner; Salma K Jabbour
Journal:  J Thorac Dis       Date:  2016-09       Impact factor: 2.895

7.  Acute Toxicity in Hypofractionated/Stereotactic Prostate Radiotherapy of Elderly Patients: Use of the Image-guided Radio Therapy (IGRT) Clarity System.

Authors:  Rossella DI Franco; Valentina Borzillo; Domingo Alberti; Gianluca Ametrano; Angela Petito; Andrea Coppolaro; Ilaria Tarantino; Sabrina Rossetti; Sandro Pignata; Gelsomina Iovane; Sisto Perdonà; Giuseppe Quarto; Giovanni Grimaldi; Alessandro Izzo; Luigi Castaldo; Raffaele Muscariello; Marcello Serra; Gaetano Facchini; Paolo Muto
Journal:  In Vivo       Date:  2021 May-Jun       Impact factor: 2.155

8.  Comparative analysis of image guidance in two institutions for prostate cancer patients.

Authors:  Tomasz Piotrowski; Slav Yartsev; George Rodrigues; Tomasz Bajon
Journal:  Rep Pract Oncol Radiother       Date:  2014-01-02

9.  Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Authors:  Sua Yoo; Q Jackie Wu; Devon Godfrey; Hui Yan; Lei Ren; Shiva Das; William R Lee; Fang-Fang Yin
Journal:  Int J Radiat Oncol Biol Phys       Date:  2009-01-01       Impact factor: 7.038

10.  A novel surface imaging system for patient positioning and surveillance during radiotherapy. A phantom study and clinical evaluation.

Authors:  F Stieler; F Wenz; M Shi; F Lohr
Journal:  Strahlenther Onkol       Date:  2013-09-27       Impact factor: 3.621

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