Literature DB >> 18022979

A small molecular scaffold for selective inhibition of Wip1 phosphatase.

Jeong Bang1, Hiroshi Yamaguchi, Stewart R Durell, Ettore Appella, Daniel H Appella.   

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Year:  2008        PMID： 18022979      PMCID： PMC3824627          DOI： 10.1002/cmdc.200700281

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  17 in total

1.  Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Authors:  Jing Li; Ying Yang; Yue Peng; Richard J Austin; Winfried G van Eyndhoven; Ken C Q Nguyen; Tim Gabriele; Mila E McCurrach; Jeffrey R Marks; Timothy Hoey; Scott W Lowe; Scott Powers
Journal:  Nat Genet       Date:  2002-05-20       Impact factor: 38.330

2.  Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

Authors:  Akinori Yoda; Xiao Zhou Xu; Nobuyuki Onishi; Kyoko Toyoshima; Hiroko Fujimoto; Naoko Kato; Isao Oishi; Takeshi Kondo; Yasuhiro Minami
Journal:  J Biol Chem       Date:  2006-06-23       Impact factor: 5.157

3.  Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.

Authors:  A K Das; N R Helps; P T Cohen; D Barford
Journal:  EMBO J       Date:  1996-12-16       Impact factor: 11.598

4.  The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

Authors:  O N Demidov; C Kek; S Shreeram; O Timofeev; A J Fornace; E Appella; D V Bulavin
Journal:  Oncogene       Date:  2006-10-02       Impact factor: 9.867

5.  The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.

Authors:  M Oliva-Trastoy; V Berthonaud; A Chevalier; C Ducrot; M-C Marsolier-Kergoat; C Mann; F Leteurtre
Journal:  Oncogene       Date:  2006-08-28       Impact factor: 9.867

6.  Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.

Authors:  M Fiscella; H Zhang; S Fan; K Sakaguchi; S Shen; W E Mercer; G F Vande Woude; P M O'Connor; E Appella
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

7.  Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.

Authors:  D V Bulavin; S Saito; M C Hollander; K Sakaguchi; C W Anderson; E Appella; A J Fornace
Journal:  EMBO J       Date:  1999-12-01       Impact factor: 11.598

8.  Substrate specificity of the human protein phosphatase 2Cdelta, Wip1.

Authors:  Hiroshi Yamaguchi; Giuseppina Minopoli; Oleg N Demidov; Deb K Chatterjee; Carl W Anderson; Stewart R Durell; Ettore Appella
Journal:  Biochemistry       Date:  2005-04-12       Impact factor: 3.162

9.  The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases.

Authors:  Hiroshi Yamaguchi; Stewart R Durell; Deb K Chatterjee; Carl W Anderson; Ettore Appella
Journal:  Biochemistry       Date:  2007-10-16       Impact factor: 3.162

10.  Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.

Authors:  Sathyavageeswaran Shreeram; Weng Kee Hee; Oleg N Demidov; Calvina Kek; Hiroshi Yamaguchi; Albert J Fornace; Carl W Anderson; Ettore Appella; Dmitry V Bulavin
Journal:  J Exp Med       Date:  2006-12-11       Impact factor: 14.307
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  4 in total

1.  Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.

Authors:  Anastasia R Goloudina; Kan Tanoue; Arlette Hammann; Eric Fourmaux; Xavier Le Guezennec; Dmitry V Bulavin; Sharlyn J Mazur; Ettore Appella; Carmen Garrido; Oleg N Demidov
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-07       Impact factor: 11.205

2.  Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).

Authors:  Ryo Hayashi; Kan Tanoue; Stewart R Durell; Deb K Chatterjee; Lisa M Miller Jenkins; Daniel H Appella; Ettore Appella
Journal:  Biochemistry       Date:  2011-05-09       Impact factor: 3.162

3.  Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1.

Authors:  Ganipisetti Srinivasrao; Jung-Eun Park; Sungmin Kim; Mija Ahn; Chaejoon Cheong; Ky-Youb Nam; Pethaiah Gunasekaran; Eunha Hwang; Nam-Hyung Kim; Song Yub Shin; Kyung S Lee; Eunkyung Ryu; Jeong Kyu Bang
Journal:  PLoS One       Date:  2014-09-11       Impact factor: 3.240

Review 4.  WIP1 phosphatase as pharmacological target in cancer therapy.

Authors:  Soňa Pecháčková; Kamila Burdová; Libor Macurek
Journal:  J Mol Med (Berl)       Date:  2017-04-24       Impact factor: 4.599
  4 in total

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