Literature DB >> 18018764

Sexual dysfunction in HIV-infected men: role of antiretroviral therapy, hypogonadism and lipodystrophy.

Giovanni Guaraldi1, Kety Luzi, Rita Murri, Antonio Granata, Maria De Paola, Gabriella Orlando, Nicola Squillace, Davide Malmusi, Cesare Carani, Dante Comelli, Roberto Esposito, Esteban Martinez.   

Abstract

BACKGROUND: Both psychological and organic factors have been recognized to be associated with sexual dysfunction in HIV-infected individuals.
METHODS: In this cross-sectional study we evaluated the prevalence and factors associated with sexual dysfunction in a cohort of HIV-infected adult men. Evaluation tools included: the International Index of Erectile Function (erectile dysfunction [ED], desire, orgasm, intercourse satisfaction, overall satisfaction), the Assessment of Body Change and Distress (body image satisfaction), the Medical Outcomes Study HIV Health Survey (mental and physical health-related quality of life), and plasma free and total testosterone level (hypogonadism).
RESULTS: Three-hundred and fifty-seven men were enrolled. Among 336 patients reporting sexual activities in the 4 weeks before, 94 (29.6%) had mild, 30 (9.4%) moderate and 34 (10.1%) severe dysfunction. The Mental Health Summary score was 2.28 units (95% confidence interval [CI] 1.51, 3.06) lower for each unit higher of body image dissatisfaction and 0.31 units (95% CI 0.27, 0.36) higher for each unit higher of the score for body change interference with habits. At regression analysis, ED was independently related to the body mass index (B = 0.31, 95% CI 0.08, 0.62). Desire, orgasm and overall satisfaction domains were associated with mental health score (B = 0.87, 95% CI 0.47, 1.27; B = 0.75, 95% CI 0.23, 1.26; B = 0.86, 95% CI 0.45, 1.28, respectively). An improved intercourse satisfaction domain was associated with a lower interference of body changes with habits and social life (B = 0.39, 95% CI 0.05, 0.73). Testosterone, metabolic alterations and HAART were not associated with sexual function domains.
CONCLUSIONS: Body image and mental health but not HAART or hypogonadism were associated with sexual function domains.

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Year:  2007        PMID: 18018764     DOI: 10.1177/135965350701200713

Source DB:  PubMed          Journal:  Antivir Ther        ISSN: 1359-6535


  14 in total

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Authors:  Imran Ahmed Syed; Syed Azhar Syed Sulaiman; Mohammad Azmi Hassali; Christopher K C Lee
Journal:  Health Expect       Date:  2013-09-08       Impact factor: 3.377

Review 2.  Male sexual dysfunction and HIV--a clinical perspective.

Authors:  Daniele Santi; Giulia Brigante; Stefano Zona; Giovanni Guaraldi; Vincenzo Rochira
Journal:  Nat Rev Urol       Date:  2014-01-07       Impact factor: 14.432

3.  Psychosocial risk factors of erectile dysfunction among heterosexual men living with HIV.

Authors:  Selin Akbas; Danielle C Alcéna-Stiner; James M McMahon
Journal:  AIDS Care       Date:  2022-02-08

4.  The effects of intermittent, CD4-guided antiretroviral therapy on body composition and metabolic parameters.

Authors:  Esteban Martinez; Fehmida Visnegarwala; Birgit Grund; Avis Thomas; Cynthia Gibert; Judith Shlay; Fraser Drummond; Daniel Pearce; Simon Edwards; Peter Reiss; Wafaa El-Sadr; Andrew Carr
Journal:  AIDS       Date:  2010-01-28       Impact factor: 4.177

5.  Addressing sexual problems in HIV primary care: experiences from patients.

Authors:  Theo G M Sandfort; Kate L Collier; Robert Grossberg
Journal:  Arch Sex Behav       Date:  2012-09-11

Review 6.  Urological aspects of HIV and AIDS.

Authors:  Chris F Heyns; Shaun G Smit; André van der Merwe; Amir D Zarrabi
Journal:  Nat Rev Urol       Date:  2013-10-29       Impact factor: 14.432

7.  Severity of lipodystrophy is associated with decreased health-related quality of life.

Authors:  Giovanni Guaraldi; Rita Murri; Gabriella Orlando; Chiara Giovanardi; Nicola Squillace; Marcella Vandelli; Barbara Beghetto; Giulia Nardini; Maria De Paola; Roberto Esposito; Albert W Wu
Journal:  AIDS Patient Care STDS       Date:  2008-07       Impact factor: 5.078

8.  Sexual Dysfunctions of HIV-Positive Men: Associated Factors, Pathophysiology Issues, and Clinical Management.

Authors:  Marco de Tubino Scanavino
Journal:  Adv Urol       Date:  2011-10-20

9.  Premature decline of serum total testosterone in HIV-infected men in the HAART-era.

Authors:  Vincenzo Rochira; Lucia Zirilli; Gabriella Orlando; Daniele Santi; Giulia Brigante; Chiara Diazzi; Federica Carli; Cesare Carani; Giovanni Guaraldi
Journal:  PLoS One       Date:  2011-12-09       Impact factor: 3.240

10.  Prevalence and Predictors of Erectile Dysfunctions among Men on Antiretroviral Therapy in South-western Nigeria.

Authors:  W O Adebimpe; O Omobuwa; O A Adeoye
Journal:  Ann Med Health Sci Res       Date:  2015 Jul-Aug
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