Literature DB >> 18007394

Facile synthesis of 5, 6, 7, 8-tetrahydropyrimido [4, 5-b]-quinoline derivatives.

Yehya Mahmud Elkholy1, Mohamed Abdelhamed Morsy.   

Abstract

2-Amino-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2-benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.

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Year:  2006        PMID： 18007394      PMCID： PMC6148637          DOI： 10.3390/11110890

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  8 in total

1.  Processing of X-ray diffraction data collected in oscillation mode.

Authors:  Z Otwinowski; W Minor
Journal:  Methods Enzymol       Date:  1997       Impact factor: 1.600

2.  Mechanism of action of two new pyrimidoquinoline and isoquinoline derivatives in human platelets.

Authors:  G Leoncini; M G Signorello; G C Grossi; M Di Braccio
Journal:  Thromb Res       Date:  1997-09-01       Impact factor: 3.944

3.  Synthesis and anticancer properties of pyrimido[4,5-b]quinolines.

Authors:  A Długosz; D Duś
Journal:  Farmaco       Date:  1996-05

4.  Tetrazolo[1,5-a] quinoline derivatives as anti-inflammatory and antimicrobial agents [1].

Authors:  Ola A El-Sayed; Turki M Al-Turki; Hessa M Al-Daffiri; Badr A Al-Bassam; Maher E Hussein
Journal:  Boll Chim Farm       Date:  2004 Jul-Aug

5.  Novel 4-aminopyrimido[4,5-b]quinoline derivatives as potential antimicrobial agents.

Authors:  Ola A el-Sayed; Fatma M el-Bieh; Shada I el-Aqeel; Badr A al-Bassam; Maher E Hussein
Journal:  Boll Chim Farm       Date:  2002 Nov-Dec

6.  Synthesis of some novel quinoline-3-carboxylic acids and pyrimidoquinoline derivatives as potential antimicrobial agents.

Authors:  Ola A El-Sayed; Badr A Al-Bassam; Maher E Hussein
Journal:  Arch Pharm (Weinheim)       Date:  2002-11       Impact factor: 3.751

7.  Helquinoline, a new tetrahydroquinoline antibiotic from Janibacter limosus Hel 1+.

Authors:  Ratnakar N Asolkar; Dirk Schröder; Rolf Heckmann; Siegmund Lang; Irene Wagner-Döbler; Hartmut Laatsch
Journal:  J Antibiot (Tokyo)       Date:  2004-01       Impact factor: 2.649

8.  Synthesis of certain 4-oxo-1.2.3.4-tetrahydroquinoline and benzazocine derivatives likely to possess analgesic activity.

Authors:  M A Shaaban; K M Ghoneim; M Khalifa
Journal:  Pharmazie       Date:  1977-02       Impact factor: 1.267
  8 in total
  4 in total

1.  Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones.

Authors:  Subham G Patel; Ruturajsinh M Vala; Paras J Patel; Dipti B Upadhyay; V Ramkumar; Ramesh L Gardas; Hitendra M Patel
Journal:  RSC Adv       Date:  2022-06-29       Impact factor: 4.036

2.  An efficient synthesis of pyrazolo[3,4-b]quinolin-3-amine and benzo[b][1,8]naphthyridine derivatives.

Authors:  Yehya M Elkholy
Journal:  Molecules       Date:  2007-03-08       Impact factor: 4.411

3.  Synthesis of certain pyrimidine derivatives as antimicrobial agents and anti-inflammatory agents.

Authors:  Mosaad S Mohamed; Samir M Awad; Amira Ibrahim Sayed
Journal:  Molecules       Date:  2010-03-15       Impact factor: 4.411

4.  ZnCl2-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones.

Authors:  Ziqi Su; Hongxin Chai; Juan Xu; Jiarong Li
Journal:  RSC Adv       Date:  2021-09-06       Impact factor: 4.036
  4 in total

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