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Literature DB >> 18007391

Synthesis and biological evaluation of new 4beta-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives.

Fu-Min Zhang¹, Xiao-Jun Yao, Xuan Tian, Yong-Qiang Tu.

Abstract

A series of new 4beta-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 and A549 than the reference compound etoposide. In addition, the partition coefficients (P) of all the new and previously synthesized derivatives were determined.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2006 PMID： 18007391 PMCID： PMC6148536 DOI： 10.3390/11110849

Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411

32 in total

1. Nucleoside analogs. 14. The synthesis of antitumor activity in mice of molecular combinations of 5-fluorouracil and N-(2-Chloroethyl)-N-nitrosourea moieties separated by a three-carbon chain.

Authors: R S McElhinney; J E McCormick; M C Bibby; J A Double; M Radacic; P Dumont
Journal: J Med Chem Date: 1996-03-29 Impact factor: 7.446

2. Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities.

Authors: Raffaele Saladino; Cinzia Fiani; Maria Cristina Belfiore; Giampiero Gualandi; Sabrina Penna; Pasquale Mosesso
Journal: Bioorg Med Chem Date: 2005-11-01 Impact factor: 3.641

Review 3. Podophyllotoxin.

Authors: C Canel; R M Moraes; F E Dayan; D Ferreira
Journal: Phytochemistry Date: 2000-05 Impact factor: 4.072

Review 4. Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.

Authors: D Cunningham; R D James
Journal: Eur J Cancer Date: 2001-05 Impact factor: 9.162

5. Cytotoxic cyclolignans related to podophyllotoxin.

Authors: M Gordaliza; J M Miguel del Corral; M Angeles Castro; P A García-García; A San Feliciano
Journal: Farmaco Date: 2001-04

6. Modeling of purine derivatives transport across cell membranes based on their partition coefficient determination and quantum chemical calculations.

Authors: Marcin Hoffmann; Maria Chrzanowska; Tadeusz Hermann; Jacek Rychlewski
Journal: J Med Chem Date: 2005-06-30 Impact factor: 7.446

7. Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives.

Authors: A Dantzig; R T LaLonde; F Ramdayal; R L Shepard; K Yanai; M Zhang
Journal: J Med Chem Date: 2001-01-18 Impact factor: 7.446

Synthesis and biological evaluation of new 4beta-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives.

1. Nucleoside analogs. 14. The synthesis of antitumor activity in mice of molecular combinations of 5-fluorouracil and N-(2-Chloroethyl)-N-nitrosourea moieties separated by a three-carbon chain.

2. Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities.

Review 3. Podophyllotoxin.

Review 4. Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.

5. Cytotoxic cyclolignans related to podophyllotoxin.

6. Modeling of purine derivatives transport across cell membranes based on their partition coefficient determination and quantum chemical calculations.

7. Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives.

8. New colorimetric cytotoxicity assay for anticancer-drug screening.

9. Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates.

10. Hemi-synthesis and biological activity of new analogues of podophyllotoxin.

1. Synthesis and bioevaluation of 5-fluorouracil derivatives.

2. Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.

Review 3. 5-Fluorouracil: mechanisms of resistance and reversal strategies.