OBJECTIVE: Obsessive-compulsive disorder (OCD) comprises a number of specific symptom dimensions. The authors factor analyzed data on the Yale-Brown Obsessive Compulsive Scale symptom checklist in a large group of Japanese OCD patients to examine whether symptom dimensions were stable across cultures. METHOD: A principal components analysis of Yale-Brown Obsessive Compulsive Scale major symptom categories was performed on Japanese OCD patients (N=343). The association between symptom dimensions and clinical variables, including 1-year outcome after combination treatment, was also examined using Pearson correlations. RESULTS: Four factors explaining 57.7% of the variance were identified: 1) contamination/washing, 2) hoarding, 3) symmetry/repeating and ordering, and 4) aggressive/checking symptoms. The symmetry dimension was associated with early age at onset, and both the symmetry and hoarding dimensions were associated with decreased functioning and treatment resistance. CONCLUSIONS: The findings in this study support transcultural stability in the symptom structure of OCD, which is consistent with the hypothesis that OCD is mediated by universal psychobiological mechanisms.
OBJECTIVE:Obsessive-compulsive disorder (OCD) comprises a number of specific symptom dimensions. The authors factor analyzed data on the Yale-Brown Obsessive Compulsive Scale symptom checklist in a large group of Japanese OCDpatients to examine whether symptom dimensions were stable across cultures. METHOD: A principal components analysis of Yale-Brown Obsessive Compulsive Scale major symptom categories was performed on Japanese OCDpatients (N=343). The association between symptom dimensions and clinical variables, including 1-year outcome after combination treatment, was also examined using Pearson correlations. RESULTS: Four factors explaining 57.7% of the variance were identified: 1) contamination/washing, 2) hoarding, 3) symmetry/repeating and ordering, and 4) aggressive/checking symptoms. The symmetry dimension was associated with early age at onset, and both the symmetry and hoarding dimensions were associated with decreased functioning and treatment resistance. CONCLUSIONS: The findings in this study support transcultural stability in the symptom structure of OCD, which is consistent with the hypothesis that OCD is mediated by universal psychobiological mechanisms.
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Authors: Michael H Bloch; Angeli Landeros-Weisenberger; Maria C Rosario; Christopher Pittenger; James F Leckman Journal: Am J Psychiatry Date: 2008-10-15 Impact factor: 18.112
Authors: M H Bloch; C A Bartley; L Zipperer; E Jakubovski; A Landeros-Weisenberger; C Pittenger; J F Leckman Journal: Mol Psychiatry Date: 2014-06-10 Impact factor: 15.992
Authors: Charles B Nemeroff; Daniel Weinberger; Michael Rutter; Harriet L MacMillan; Richard A Bryant; Simon Wessely; Dan J Stein; Carmine M Pariante; Florian Seemüller; Michael Berk; Gin S Malhi; Martin Preisig; Martin Brüne; Paul Lysaker Journal: BMC Med Date: 2013-09-12 Impact factor: 8.775