| Literature DB >> 18006319 |
Douglass Wu1, Masakazu Fujio, Chi-Huey Wong.
Abstract
The processing and presentation of lipid antigens by antigen presenting cells (APC) is important for defense against infection, tumor immunosurveillance, and autoimmunity. CD1, a family of cell surface glycoproteins, is responsible for the binding and presentation of lipid antigens to receptors expressed on the surface of T lymphocytes. Among the several (glyco)lipids identified to cause T-cell stimulation in complex with CD1, alpha-galactosyl ceramide (alpha-GalCer) is one of the most well studied. A combination of structure-activity relationship (SAR), crystallographic studies, and discovery of new 'natural' antigens has led to greater understanding of the structural requirements for optimal natural killer T-cell activation.Entities:
Mesh：
Substances：
Year: 2007 PMID： 18006319 PMCID： PMC2279229 DOI： 10.1016/j.bmc.2007.10.026
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641